[Role of the glia in neuropathic pain caused by peripheral nerve injury].
[Role of the glia in neuropathic pain caused by peripheral nerve injury].
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发表时间：
2012-11
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通讯作者：
Kazuhide Inoue;M. Tsuda;H. Tozaki-Saitoh
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作者：
Kazuhide Inoue;M. Tsuda;H. Tozaki-Saitoh
神经性疼痛通常是由于手术、癌症、骨压迫、糖尿病或感染引起的神经损伤的结果。这种类型的疼痛可能非常严重，即使是最轻微的触摸也会导致受影响区域的剧烈疼痛。神经性疼痛通常对目前可用的治疗有抗性。文献中的大量证据表明，活化的小胶质细胞和星形胶质细胞是神经病理性疼痛的关键参与者，并且胶质细胞中表达的ATP受体在疼痛信号传导中具有重要作用。本文综述了小胶质细胞在ATP受体功能中的作用以及星形胶质细胞在神经病理性疼痛中的作用。了解小胶质细胞和星形胶质细胞的关键功能可能会导致开发新的策略来管理顽固性慢性疼痛。
Neuropathic pain is often a consequence of nerve injury due to surgery, cancer, bone compression, diabetes, or infection. This type of pain can be so severe that even the slightest touch can cause intense pain in the affected area. Neuropathic pain is generally resistant to currently available treatments. Abundant evidence in the literature suggests that activated microglia and astrocytes are key players in neuropathic pain and that ATP receptors expressed in the glia have an important role in pain signaling. In this review, we summarize the roles of the microglia in the functioning of ATP receptors and of the astrocytes in neuropathic pain. Understanding the key functions of the microglia and astrocytes may lead to the development of new strategies for the management of intractable chronic pain.