The Association between Plasma Levels of Trimethylamine N-Oxide and the Risk of Coronary Heart Disease in Chinese Patients with or without Type 2 Diabetes Mellitus.
The Association between Plasma Levels of Trimethylamine N-Oxide and the Risk of Coronary Heart Disease in Chinese Patients with or without Type 2 Diabetes Mellitus.
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DOI：
10.1155/2018/1578320
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Hai X
中科院分区：
文献类型：
--
作者：
Dong Z;Liang Z;Guo M;Hu S;Shen Z;Hai X
三甲胺 N-氧化物 (TMAO) 已被证明是心血管疾病的独立危险因素。我们的目的是测定患有或不患有 2 型糖尿病 (T2DM) 的中国冠心病 (CHD) 患者的血浆 TMAO 水平。 共有 132 名对照参与者、243 名 CHD 患者和 175 名 CHD 合并 T2DM 患者入组。测量并分析所有患者的血浆TMAO水平。 CHD患者血浆TMAO水平显着高于对照组（3.08±0.13μM vs 1.49±0.05μM；P < 0.01）。此外，与CHD患者相比，CHD合并T2DM患者血浆TMAO水平显着升高（7.63±0.97μM vs 3.08±0.13μM；P < 0.01）。受试者工作特征分析显示，TMAO 预测 CHD 或 CHD-T2DM 患者的曲线下面积分别为 0.794 和 0.927（P < 0.01）。单变量和多变量 Logistic 回归分析显示，TMAO 是伴或不伴 T2DM 的 CHD 患者的独立预测因子。 TMAO 水平与高敏肌钙蛋白 I (hs-TnI) 和肌酸激酶 MB (CKMB) 相关。 TMAO 是中国患者冠心病的独立预测因子；此外，TMAO水平与冠心病患者的糖尿病高度相关。
Trimethylamine N-oxide (TMAO) has been demonstrated as an independent risk factor for cardiovascular disease. Our objective was to determine the plasma levels of TMAO in Chinese coronary heart disease (CHD) patients with or without type 2 diabetes mellitus (T2DM). A total of 132 control participants, 243 CHD patients, and 175 CHD patients with T2DM were enrolled. Plasma levels of TMAO in all patients were measured and analyzed. The plasma levels of TMAO were significantly higher in CHD patients than in control subjects (3.08 ± 0.13 μM versus 1.49 ± 0.05 μM; P < 0.01). In addition, plasma levels of TMAO were remarkably increased in CHD patients with T2DM compared with CHD patients (7.63 ± 0.97 μM versus 3.08 ± 0.13 μM; P < 0.01). The receiver operating characteristic analysis revealed that the area under the curve of TMAO was 0.794 and 0.927 to predict CHD or CHD-T2DM patients (P < 0.01). Univariate and multivariate logistic regression analysis showed that TMAO was an independent predictor in CHD patients with or without T2DM. The level of TMAO was correlated with high-sensitive troponin I (hs-TnI) and creatine kinase MB (CKMB). TMAO was an independent predictor of CHD in Chinese patients; moreover, the TMAO levels were highly associated with diabetes in CHD patients.
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影响因子：
3.5
作者：
Maria Oliver, Jose;Gallego, Pastora;Fernandez-Aviles, Francisco
通讯作者：
Fernandez-Aviles, Francisco
DOI：
10.1056/nejmoa1109400
发表时间：
2013-04-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Tang WH;Wang Z;Levison BS;Koeth RA;Britt EB;Fu X;Wu Y;Hazen SL
通讯作者：
Hazen SL
DOI：
10.1159/000484623
发表时间：
2017
期刊：
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
影响因子：
--
作者：
Boini KM;Hussain T;Li PL;Koka S
通讯作者：
Koka S
影响因子：
5.7
作者：
Suzuki, Toru;Heaney, Liam M.;Ng, Leong L.
通讯作者：
Ng, Leong L.
DOI：
10.1016/j.bbrc.2017.12.069
发表时间：
2018-01-08
影响因子：
3.1
作者：
Li, Tiejun;Gua, Chaojun;Chen, Yanli
通讯作者：
Chen, Yanli