The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer.
The in vivo study on the radiobiologic effect of prolonged delivery time to tumor control in C57BL mice implanted with Lewis lung cancer.
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DOI：
10.1186/1748-717x-6-4
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发表时间：
2011-01-12
期刊：
影响因子：
--
通讯作者：
Ying HM
中科院分区：
文献类型：
--
作者：
Wang X;Xiong XP;Lu J;Zhu GP;He SQ;Hu CS;Ying HM
IMRT 或立体定向放射外科等高精度放射治疗技术可提供比传统技术更复杂的治疗领域。复杂性的增加导致每个部分的剂量输送时间更长。这项工作的目的是探讨延长分数递送时间对体内肿瘤反应和存活的放射生物学影响。使用生长在 C57BL 小鼠腿部的直径 1 厘米的 Lewis 肺癌肿瘤。为了评估剂量递送延长的效果，将 18 Gy 分为不同的亚分数。 48只小鼠随机分为6组:正常对照组、单次18 Gy组、2个亚次分割30 min组、7个亚次分割5 min组、2个亚次分割60 min组、7个亚次分割10 min组。分析肿瘤生长趋势、肿瘤生长延迟和小鼠存活时间。延长给药时间组肿瘤生长延迟时间短于单次18 Gy组（P < 0.05）。延长给药时间30 min组的肿瘤生长延迟时间长于延长给药时间60 min组（P < 0.05）。相同分娩时间组间差异无统计学意义（P>0.05）。与单次18 Gy组相比，延长给药时间组缩短了小鼠的存活时间，而延长给药时间30 min组和延长给药时间60 min组之间无显着差异。相同辐射剂量下延长的递送时间缩短了植入Lewis肺癌的小鼠的肿瘤生长延迟和生存时间。抗肿瘤作用随着总间隔时间的延长而降低。
High-precision radiation therapy techniques such as IMRT or sterotactic radiosurgery, delivers more complex treatment fields than conventional techniques. The increased complexity causes longer dose delivery times for each fraction. The purpose of this work is to explore the radiobiologic effect of prolonged fraction delivery time on tumor response and survival in vivo. 1-cm-diameter Lewis lung cancer tumors growing in the legs of C57BL mice were used. To evaluate effect of dose delivery prolongation, 18 Gy was divided into different subfractions. 48 mice were randomized into 6 groups: the normal control group, the single fraction with 18 Gy group, the two subfractions with 30 min interval group, the seven subfractions with 5 min interval group, the two subfractions with 60 min interval group and the seven subfractions with 10 min interval group. The tumor growth tendency, the tumor growth delay and the mice survival time were analyzed. The tumor growth delay of groups with prolonged delivery time was shorter than the group with single fraction of 18 Gy (P < 0.05). The tumor grow delay of groups with prolonged delivery time 30 min was longer than that of groups with prolonged delivery time 60 min P < 0.05). There was no significant difference between groups with same delivery time (P > 0.05). Compared to the group with single fraction of 18 Gy, the groups with prolonged delivery time shorten the mice survival time while there was no significant difference between the groups with prolonged delivery time 30 min and the groups with prolonged delivery time 60 min. The prolonged delivery time with same radiation dose shorten the tumor growth delay and survival time in the mice implanted with Lewis lung cancer. The anti-tumor effect decreased with elongation of the total interfractional time.