A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide.
A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide.
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DOI：
10.1016/j.molcel.2014.03.012
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发表时间：
2014-04-24
期刊：
影响因子：
16
通讯作者：
Kagan, Jonathan C.
中科院分区：
文献类型：
--
作者：
Tan, Yunhao;Kagan, Jonathan C.
对细菌天然免疫的研究主要集中在哺乳动物细胞检测脂多糖的机制上，脂多糖是革兰氏阴性细菌的保守表面成分。虽然Toll样受体4(TLR4)负责宿主对内毒素的所有转录反应，但最近的发现揭示了存在几种TLR4不依赖于TLR4的对内毒素的反应。这些发现不仅拓宽了我们对哺乳动物细胞与细菌相互作用方式的看法，还突显了可能促进细菌免疫逃避策略进化的新的选择压力。在这篇综述中，我们重点介绍了过去和最近在宿主内毒素感应机制方面的发现，并讨论了促进感染的细菌对策。通过观察寄主-病原菌相互作用方程的两个方面，我们希望对寄主防御机制和细菌的致病机理提供全面的见解。
The study of innate immunity to bacteria has focused heavily on the mechanisms by which mammalian cells detect lipopolysaccharide (LPS), the conserved surface component of gram-negative bacteria. While Toll-like Receptor 4 (TLR4) is responsible for all the host transcriptional responses to LPS, recent discoveries have revealed the existence of several TLR4-independent responses to LPS. These discoveries not only broaden our view of the means by which mammalian cells interact with bacteria, but also highlight new selective pressures that may have promoted the evolution of bacterial immune evasion strategies. In this review, we highlight past and recent discoveries on host LPS sensing mechanisms and discuss bacterial countermeasures that promote infection. By looking at both sides of the host-pathogen interaction equation, we hope to provide comprehensive insights into host defense mechanisms and bacterial pathogenesis.
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影响因子：
3.4
作者：
Coats SR;Jones JW;Do CT;Braham PH;Bainbridge BW;To TT;Goodlett DR;Ernst RK;Darveau RP
通讯作者：
Darveau RP
影响因子：
4.8
作者：
Chiang, Chih-Yuan;Veckman, Ville;David, Michael
通讯作者：
David, Michael
影响因子：
64.5
作者：
Dixit E;Boulant S;Zhang Y;Lee AS;Odendall C;Shum B;Hacohen N;Chen ZJ;Whelan SP;Fransen M;Nibert ML;Superti-Furga G;Kagan JC
通讯作者：
Kagan JC
影响因子：
30.5
作者：
Arbibe, Laurence;Kim, Dong Wook;Sansonetti, Philippe J.
通讯作者：
Sansonetti, Philippe J.
DOI：
10.1177/09680519010070040901
发表时间：
2001-01-01
期刊：
JOURNAL OF ENDOTOXIN RESEARCH
影响因子：
--
作者：
Beutler, B;Du, X;Poltorak, A
通讯作者：
Poltorak, A