A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides
A new one step synthesis of maleimides by condensation of glyoxylate esters with acetamides
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DOI：
10.1016/s0040-4039(98)02594-5
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发表时间：
1999-02-05
影响因子：
1.8
通讯作者：
Krumrich, CA
中科院分区：
文献类型：
--
作者：
Faul, MM;Winneroski, LL;Krumrich, CA
用1.0 M叔丁醇钾的THF溶液，通过乙醛酸酯与乙酰胺的缩合，一步制得双苯基、双杂芳基、吲哚基芳基和吲哚基环烷基马来酰亚胺，产率为67-99%。对反应机理进行了讨论。(C)1999由Elsevier Science Ltd.出版。保留所有权利。
Bisphenyl, bisheteroaryl, indolylaryl and indolylcycloalkyl maleimides are prepared in one step and 67-99% yield by condensation of glyoxylate esters with acetamides using a 1.0 M solution of potassium tert-butoxide in THF. The mechanism of the reaction is discussed. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.