Oesophageal Stem Cells and Cancer.
Oesophageal Stem Cells and Cancer.
复制标题
食管干细胞和癌症。
DOI：
10.1007/978-3-319-69194-7_10
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发表时间：
2017
影响因子：
--
通讯作者：
Alcolea MP
中科院分区：
文献类型：
--
作者：
Alcolea MP
食管癌仍然是研究最少的恶性肿瘤之一。然而，近年来，其发病率的增加和预后不良，激发了癌症社区的兴趣，以了解疾病的起始和进展的途径。对控制干细胞命运变化的分子过程及其与相邻基质邻居的相互作用的关键理解将为食管癌发生中出错的机制提供必要的知识。谱系追踪技术的进展代表了一个强大的工具，开始了解食管细胞行为的变化，以响应有利于肿瘤发展的突变和诱变剂。环境因素是食管癌发病的重要因素。食管上皮是暴露于恶劣条件下的组织，其不仅损伤上皮细胞的DNA，而且导致活跃的基质反应，促进肿瘤进展。最终，癌症代表了恶性细胞与其微环境之间的复杂相互作用。事实上，越来越多的证据表明，体细胞突变的积累并不是癌症的唯一原因。相反，来自基质的非细胞自主成分可以在肿瘤形成的最早阶段起重要作用。基质细胞在癌症中发挥重要作用的认识已经将这种细胞区室转变为一个有吸引力的新兴研究领域。越来越清楚的是，肿瘤微环境为识别早期诊断和预后标志物以及可能与靶向肿瘤细胞协同作用的潜在治疗策略提供了独特的机会。本章汇编了最近对食管上皮干细胞生物学的观察，以及环境和微环境变化如何导致食管疾病和癌症。
Oesophageal cancer remains one of the least explored malignancies. However, in recent years its increasing incidence and poor prognosis have stimulated interest from the cancer community to understand the pathways to the initiation and progression of the disease. Critical understanding of the molecular processes controlling changes in stem cell fate and the cross-talk with their adjacent stromal neighbours will provide essential knowledge on the mechanisms that go awry in oesophageal carcinogenesis. Advances in lineage tracing techniques have represented a powerful tool to start understanding changes in oesophageal cell behaviour in response to mutations and mutagens that favour tumour development. Environmental cues constitute an important factor in the aetiology of oesophageal cancer. The oesophageal epithelium is a tissue exposed to harsh conditions that not only damage the DNA of epithelial cells but also result in an active stromal reaction, promoting tumour progression. Ultimately, cancer represents a complex interplay between malignant cells and their microenvironment. Indeed, increasing evidence suggests that the accumulation of somatic mutations is not the sole cause of cancer. Instead, non-cell autonomous components, coming from the stroma, can significantly contribute from the earliest stages of tumour formation. The realisation that stromal cells play an important role in cancer has transformed this cellular compartment into an attractive and emerging field of research. It is becoming increasingly clear that the tumour microenvironment provides unique opportunities to identify early diagnostic and prognostic markers, as well as potential therapeutic strategies that may synergise with those targeting tumour cells. This chapter compiles recent observations on oesophageal epithelial stem cell biology, and how environmental and micro-environmental changes may lead to oesophageal disease and cancer.
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影响因子：
--
作者：
Chen MF;Kuan FC;Yen TC;Lu MS;Lin PY;Chung YH;Chen WC;Lee KD
通讯作者：
Lee KD
影响因子：
30.8
作者：
Dulak, Austin M.;Stojanov, Petar;Peng, Shouyong;Lawrence, Michael S.;Fox, Cameron;Stewart, Chip;Bandla, Santhoshi;Imamura, Yu;Schumacher, Steven E.;Shefler, Erica;McKenna, Aaron;Carter, Scott L.;Cibulskis, Kristian;Sivachenko, Andrey;Saksena, Gordon;Voet, Douglas;Ramos, Alex H.;Auclair, Daniel;Thompson, Kristin;Sougnez, Carrie;Onofrio, Robert C.;Guiducci, Candace;Beroukhim, Rameen;Zhou, Zhongren;Lin, Lin;Lin, Jules;Reddy, Rishindra;Chang, Andrew;Landrenau, Rodney;Pennathur, Arjun;Ogino, Shuji;Luketich, James D.;Golub, Todd R.;Gabriel, Stacey B.;Lander, Eric S.;Beer, David G.;Godfrey, Tony E.;Getz, Gad;Bass, Adam J.
通讯作者：
Bass, Adam J.
DOI：
10.12703/p5-44
发表时间：
2013-10-01
期刊：
F1000prime reports
影响因子：
--
作者：
di Pietro M;Fitzgerald RC
通讯作者：
Fitzgerald RC
影响因子：
28.2
作者：
Agrawal N;Jiao Y;Bettegowda C;Hutfless SM;Wang Y;David S;Cheng Y;Twaddell WS;Latt NL;Shin EJ;Wang LD;Wang L;Yang W;Velculescu VE;Vogelstein B;Papadopoulos N;Kinzler KW;Meltzer SJ
通讯作者：
Meltzer SJ
影响因子：
21.3
作者：
通讯作者：
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