Pathways to engineering plant intracellular NLR immune receptors.
Pathways to engineering plant intracellular NLR immune receptors.
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DOI：
10.1016/j.pbi.2023.102380
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发表时间：
2023-05
影响因子：
9.5
通讯作者：
Rafał Zdrzałek;C. Stone;Juan Carlos De la Concepcion;M. Banfield;A. Bentham
中科院分区：
文献类型：
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作者：
Rafał Zdrzałek;C. Stone;Juan Carlos De la Concepcion;M. Banfield;A. Bentham
包括气候变化和全球交换增加在内的因素将加剧植物疾病的流行，对全球粮食安全构成前所未有的威胁，并使满足不断增长的人口需求更具挑战性。因此，新的病原体控制方法对于帮助应对因植物病害造成的作物损失日益增加的危险至关重要。植物的细胞内免疫系统利用核苷酸结合的富含亮氨酸重复序列（NLR）受体来识别并激活对递送至宿主的病原体毒力蛋白（效应物）的防御反应。工程化植物NLR对病原体效应物的识别特性是具有高特异性的植物疾病的遗传解决方案，并且它比经常依赖于农用化学品的几种当前用于病原体控制的方法更可持续。在这里，我们强调的开拓性的方法，以提高植物NLR的效应识别，并讨论工程植物细胞内免疫系统的障碍和解决方案。
Factors including climate change and increased global exchange are set to escalate the prevalence of plant diseases, posing an unprecedented threat to global food security and making it more challenging to meet the demands of an ever-growing population. As such, new methods of pathogen control are essential to help with the growing danger of crop losses to plant diseases. The intracellular immune system of plants utilizes nucleotide-binding leucine-rich repeat (NLR) receptors to recognize and activate defense responses to pathogen virulence proteins (effectors) delivered to the host. Engineering the recognition properties of plant NLRs toward pathogen effectors is a genetic solution to plant diseases with high specificity, and it is more sustainable than several current methods for pathogen control that frequently rely on agrochemicals. Here, we highlight the pioneering approaches toward enhancing effector recognition in plant NLRs and discuss the barriers and solutions in engineering the plant intracellular immune system.