Relationship between serum adiponectin and leptin concentrations and body fat distribution
Relationship between serum adiponectin and leptin concentrations and body fat distribution
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DOI：
10.1016/j.diabres.2003.09.010
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发表时间：
2004-02-01
影响因子：
5.1
通讯作者：
Lee, IK
中科院分区：
文献类型：
--
作者：
Park, KG;Park, KS;Lee, IK
本研究的目的是探讨脂联素和瘦素与体脂分布的关系。197名女性参与了这项研究。受试者根据其内脏脂肪组织面积（VAT）进行分组。通过计算机断层扫描确定体脂分布。皮下脂肪优势组（SFDG）和内脏脂肪优势组（VFDG）分别为79例和118例。VFDG组的脂联素水平低于SFDG组（8.9 +/- 0.4 mug/ml vs 11.4 +/- 0.7 mug/ml，P = 0.006），但两组间的瘦素水平无显著差异（18.8 +/- 1.1 ng/ml vs 17.7 +/- 1.8 ng/ml，P = 0.111）。脂联素水平与空腹胰岛素、HOMA-IR、甘油三酯、收缩压、舒张压、皮下脂肪组织面积、腰臀比呈负相关。瘦素水平与空腹血糖、胰岛素、HOMA-IR、甘油三酯、收缩压、舒张压、谷丙转氨酶、SAT、腰臀比呈正相关（P均< 0.05）。增值税和高密度脂蛋白胆固醇是脂联素浓度的独立变量（R-2 = 0.207，P < 0.0001），SAT、空腹胰岛素和HOMA-IR是瘦素浓度的独立变量（R-2 = 0.498，P < 0.0001）总之，脂联素和瘦素浓度虽然与代谢参数相关，在脂联素的情况下，受VAT的影响更大，在瘦素的情况下，受SAT的影响更大。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
The aim of this study was to investigate the relationship between adiponectin and leptin and body fat distribution. One hundred and ninety-seven women participated in this study. Subjects were grouped based on their visceral adipose tissue area (VAT). Body fat distribution was determined by computed tomography. The numbers in the subcutaneous fat dominant group (SFDG) and visceral fat dominant group (VFDG) were 79 and 118, respectively. The VFDG showed lower adiponectin levels than the SFDG (8.9 +/- 0.4 mug/ml versus 11.4 +/- 0.7 mug/ml, P = 0.006), but leptin levels did not differ significantly between groups (18.8 +/- 1.1 ng/ml versus 17.7 +/- 1.8 ng/ml, P = 0.111). Adiponectin levels were-inversely correlated with fasting insulin, HOMA-IR, triglyceride, SBP and DBP, subcutaneous adipose tissue area (SAT) and VAT, and waist-to-hip ratio (WHR). Leptin levels were positively correlated with fasting glucose and insulin; HOMA-IR, triglyceride, SBP and DBP, VAT and SAT, and WHR (all values of P < 0.05). VAT and HDL-cholesterol were independent variables of adiponectin concentrations (R-2 = 0.207, P < 0.0001), and SAT, fasting insulin, and HOMA-IR were independent variables of leptin concentrations (R-2 = 0.498, P < 0.0001) In conclusion, adiponectin and leptin concentrations, although associated with metabolic parameters, were more strongly influenced by VAT in the case of adiponectin, and by SAT in the case of leptin. (C) 2003 Elsevier Ireland Ltd. All rights reserved.