Cell Model Approach to Membrane Mediated Protein Interactions(Frontiers in Nonequilibrium Physics-Fundamental Theory, Glassy & Granular Materials, and Computational Physics-)
Cell Model Approach to Membrane Mediated Protein Interactions(Frontiers in Nonequilibrium Physics-Fundamental Theory, Glassy & Granular Materials, and Computational Physics-)
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膜介导的蛋白质相互作用的细胞模型方法（非平衡物理前沿-基础理论，Glassy）
DOI：
10.1143/ptps.184.351
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发表时间：
2010
影响因子：
--
通讯作者：
M. Deserno
中科院分区：
文献类型：
--
作者：
M. Müller;M. Deserno
膜变形蛋白可以通过它们产生的曲率场相互作用。对于许多这样的蛋白质，可以使用细胞模型方法来计算每种蛋白质的能量，并预测它是否会导致相分离或芽形成。利用协变微分几何方法，根据单元边界的几何性质，得到了侧向压力的精确结果。在高度非线性区域找到了精确形状方程的数值解，可以看到相分离和萌芽形成都可以发生。
Membrane-deforming proteins can interact through the curvature fields they create. In the case of many such proteins a cell model approach can be used to calculate the energy per protein and predict, whether it would lead to phase segregation or bud-formation. Using covariant differential geometry exact results are derived for the lateral pressure in terms of geometric properties at the cell boundary. Numerical solutions of the exact shape equations in the highly nonlinear regime are found and it is seen that both phase segregation and bud formation can occur.