Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial
Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial
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DOI：
10.1152/japplphysiol.00264.2003
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发表时间：
2003-09-01
影响因子：
3.3
通讯作者：
Heer, M
中科院分区：
文献类型：
--
作者：
Baecker, N;Tomic, A;Heer, M
该研究的目的是分析骨转换的短期变化的动力学。我们采用随机交叉设计，对8名健康男性受试者(平均体重：70.1+/-5.7公斤；平均年龄：25.5+/-2.9岁)进行6天卧床休息的影响研究。代谢病房分为3个部分：4个活动日，6个卧床或非卧床休息期，1个恢复期。卧床休息阶段和非卧床休息阶段的饮食是相同的。在代谢病房的第一天开始连续采集尿液，分析骨吸收标志物，即C-端肽(CTX)和N-端肽(NTX)、肌酐、尿素和3-甲基组氨酸的排泄。在卧床第二天和卧床第五天或在非卧床阶段，抽血分析骨形成标志物和氨基酸浓度。尿钙排泄量早在卧床第一天就增加(P<；0.01)。卧床前24小时CTX和NTX排泄量与非卧床相比无明显变化。然而，在第二天，两种吸收标记物都已显著增加。NTX排泄量增加28.7+/-14.0%(P<；0.01)，而CTX排泄量增加17.8+/-8.3%(P<；0.001)。肌酐、尿素和3-甲基组氨酸的排泄量没有变化。我们的结论是，24小时的卧床休息足以诱导健康受试者破骨细胞活性的显著增加。
The aim of the study was to analyze the kinetics of short-term changes in bone turnover. We studied in a randomized crossover design the effects of 6 days of bed rest on eight healthy male subjects (mean body wt: 70.1 +/- 5.7 kg; mean age: 25.5 +/- 2.9 yr). The metabolic ward period was divided into three parts: 4 ambulatory days, 6 days of either bed rest or non-bed rest periods, and 1 recovery day. The diet was identical in both bed rest and non-bed rest phases. Continuous urine collection started on the first day in the metabolic ward to analyze excretion of bone resorption markers, namely C-telopeptide (CTX) and N-telopeptide (NTX), creatinine, urea, and 3-methylhistidine. On the second ambulatory day and on the fifth day of bed rest or during the non-bed rest phase, blood was drawn to analyze bone formation markers and amino acid concentrations. Urinary calcium excretion was increased as early as the first day of bed rest (P < 0.01). CTX and NTX excretion stayed unchanged during the first 24 h of bed rest compared with the non-bed rest period. However, already on the second day, both resorption markers had increased significantly. NTX excretion increased by 28.7 +/- 14.0% (P < 0.01), whereas CTX excretion rose by 17.8 +/- 8.3% (P < 0.001). Creatinine, urea, and 3-methylhistidine excretion did not change. We conclude that 24 h of bed rest are sufficient to induce a significant rise in osteoclast activity in healthy subjects.