Organic brain syndrome and aging. A six-year follow-up of surviving twins.
Organic brain syndrome and aging. A six-year follow-up of surviving twins.
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器质性脑综合症和衰老。
DOI：
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发表时间：
1980
影响因子：
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通讯作者：
S. Matsuyama
中科院分区：
文献类型：
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作者：
L. Jarvik;V. Ruth;S. Matsuyama
有机脑综合征（OBS）的发展研究了一个小组幸存者从纵向调查衰老的双胞胎。在初步评估时，中度至重度OBS的发生率为25%。在大约六年后进行第二次精神病学评估的22名幸存者中，在首次检查中没有OBS的人中，OBS发展的正确率为16%。因此，绝大多数在80岁左右被诊断为无OBS的人在随后的几年里仍然没有症状，这支持了OBS不是老年必然伴随的观点，而是应该寻求预防和治疗的疾病的结果。最初被诊断为OBS的人死亡率更高，这一观察结果与先前的文献报道一致。在本研究中，死亡率的增加与OBS的严重程度有关，但显然与共存的身体疾病无关，这再次支持了OBS代表病理性衰老与生理性衰老不同的观点。
The development of organic brain syndrome (OBS) was studied in a small group of survivors from a longitudinal investigation of aging twins. At the time of initial evaluation, the frequency of moderate to severe OBS was 25%. Among the 22 survivors who had a second psychiatric evaluation after approximately six years, the corrected rate for the development of OBS among those without it at the initial examination was 16%. Thus, the vast majority of those diagnosed as being without OBS at about the age of 80 years remained asymptomatic in subsequent years, supporting the view that OBS is not a necessary concomitant of old age, but the result of disease for which prevention and cure should be sought. Persons originally diagnosed as having OBS had the higher mortality, an observation in accord with prior reports in the literature. In the present study, the increased mortality was related to the severity of OBS but apparently independent of coexisting physical illness, again supporting the argument that OBS represents pathological as distinct from physiological aging.