Drosophila Acquires a Long-Lasting Body-Size Memory from Visual Feedback
Drosophila Acquires a Long-Lasting Body-Size Memory from Visual Feedback
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DOI：
10.1016/j.cub.2019.04.037
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发表时间：
2019-06-03
期刊：
影响因子：
9.2
通讯作者：
Strauss, Roland
中科院分区：
文献类型：
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作者：
Krause, Tammo;Spindler, Laura;Strauss, Roland
抓住物体或穿越战壕需要将我们四肢的操作距离信息与精确的距离估计相结合。我们的手的范围和腿的步幅是通过我们在行动过程中获得的视觉反馈来了解的。这种关于我们的个人空间的隐性知识首先是在婴儿期获得的，但会在我们的一生中不断更新[1]。相比之下，全变态昆虫的体型在变态后不会发生变化；然而，他们必须学会自己的身体至少达到一次。根据食物质量和温度等环境因素，果蝇的体型大小可能会存在约 15% 的差异 [2]。为了研究果蝇如何获取有关并记住其身体尺寸的知识，我们研究了它们避免或开始攀爬超过其身体尺寸的间隙的决定[3]。天真的（黑种）果蝇高估了它们的大小，并且必须从行走时环境中物体的视网膜图像的视差运动中学习它。天真的果蝇可以在条纹竞技场中接受训练，并通过操纵来低估它们的大小，但一旦巩固，这种记忆似乎会持续一生。这种记忆的巩固仅在训练后的前 2 小时内对压力敏感，但在接下来的 12 小时内无法恢复。我们已经确定了中央复合体原脑桥的一组内在的侧向神经元 [4, 5]，它们依赖于 dCREB2 转录活性来进行长期记忆巩固和维持。
Grasping an object or crossing a trench requires the integration of information on the operating distance of our limbs with precise distance estimation. The reach of our hands and step size of our legs are learned by the visual feedback we get during our actions. This implicit knowledge of our peripersonal space is first acquired during infancy but will be continuously updated throughout our whole life [1]. In contrast, body size of holometabolous insects does not change after metamorphosis; nevertheless, they do have to learn their body reaches at least once. The body size of Drosophila imagines can vary by about 15% depending on environmental factors like food quality and temperature [2]. To investigate how flies acquire knowledge about and memorize their body size, we studied their decisions to either refrain from or initiate climbing over gaps exceeding their body size [3]. Naive (darkreared) flies overestimate their size and have to learn it from the parallax motion of the retinal images of objects in their environment while walking. Naive flies can be trained in a striped arena and manipulated to underestimate their size, but once consolidated, this memory seems to last for a lifetime. Consolidation of this memory is stress sensitive only in the first 2 h after training but cannot be retrieved for the next 12 h. We have identified a set of intrinsic, lateral neurons of the protocerebral bridge of the central complex [4, 5] that depend on dCREB2 transcriptional activity for long-term memory consolidation and maintenance.