Advances in the previous two decades in our understanding of the post-translational modifications, functions, and drug perspectives of ArgBP2 and its family members
Advances in the previous two decades in our understanding of the post-translational modifications, functions, and drug perspectives of ArgBP2 and its family members
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过去二十年我们对 ArgBP2 及其家族成员的翻译后修饰、功能和药物前景的理解取得了进展
DOI：
10.1016/j.biopha.2022.113853
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yuxin Tong
中科院分区：
文献类型：
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作者：
Siyu Zhang;Yuxin Tong
精氨酸激酶结合蛋白2（ArgBP 2）是属于sorbin同源（SoHo）家族的衔接蛋白。SoHo家族还包括c-Cbl相关蛋白（CAP）和vinexin，两者都与ArgBP 2具有结构和功能相似性。然而，SoHo家族蛋白在细胞信号传导、耐药性、代谢和疾病，特别是癌症中的作用尚未完全了解。在此，我们总结了SoHo家族蛋白质的结构，它们的翻译后修饰和这些蛋白质调控的细胞通路的综合网络，重点是ArgBP 2。我们还讨论了SoHo家族蛋白在脂筏分布，细胞外基质相关微环境和药物发现中的相关性。该综述提供了针对ArgBP 2和其他SoHo家族蛋白作为临床前试验药物的可能性的见解。
Arginine kinase-binding protein 2 (ArgBP2) is an adapter protein that belongs to the sorbin homology (SoHo) family. The SoHo family also includes c-Cbl-associated protein (CAP) and vinexin, both of which share structural and functional similarities to ArgBP2. However, the role of SoHo family proteins in cell signaling, drug resistance, metabolism, and diseases, especially cancer, is not fully understood. Herein, we summarize the structure of SoHo family proteins, their post-translational modifications and the comprehensive network of cellular pathways regulated by these proteins, with an emphasis on ArgBP2. We also discuss the relevance of the SoHo family proteins in lipid raft distribution, extracellular matrix-associated microenvironments, and drug discovery. This review provides insights into the possibility of targeting ArgBP2 and other SoHo family proteins as drugs for use in preclinical trials.