Endogenous regulation of macrophage proliferative expansion by colony-stimulating factor-induced interferon.
Endogenous regulation of macrophage proliferative expansion by colony-stimulating factor-induced interferon.
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集落刺激因子诱导的干扰素对巨噬细胞增殖扩张的内源性调节。
DOI：
10.1126/science.6606850
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Rouse,BT
中科院分区：
文献类型：
--
作者：
Moore,RN;Larsen,HS;Horohov,DW;Rouse,BT
用特定的巨噬细胞生长因子（集落刺激因子1）刺激小鼠骨髓细胞培养物，导致1型干扰素的产生。用针对干扰素α和β的抗血清中和这种内源性干扰素，导致定向骨髓前体的单核吞噬细胞增殖显着增强。抗血清的效果在去除粘附细胞的培养物中丧失，这表明骨髓中的粘附调节细胞（或细胞）通过响应高水平的特异性生长因子产生抗增殖干扰素来限制单核吞噬细胞增殖。
Stimulation of cultures of murine bone-marrow cells with specific macrophage growth factor (colony-stimulating factor 1) resulted in the production of type 1 interferon. Neutralization of this endogenous interferon by antiserum directed against interferons α and β resulted in a significant enhancement of mononuclear phagocyte proliferation from committed marrow precursors. The effect of the antiserum was lost in cultures depleted of adherent cells, an indication that an adherent regulatory cell (or cells) in the marrow limits mononuclear phagocyte proliferation by producing antiproliferative interferon in response to high levels of specific growth factor.