Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts.
Cytoglobin as a Marker of Hepatic Stellate Cell-derived Myofibroblasts.
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DOI：
10.3389/fphys.2015.00329
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发表时间：
2015
影响因子：
4
通讯作者：
Kawada N
中科院分区：
文献类型：
--
作者：
Kawada N
肌成纤维细胞在慢性肝脏炎症、纤维化和肿瘤发生中起重要作用。肝肌成纤维细胞起源于肝星状细胞、门静脉成纤维细胞或间皮细胞，它们位于纤维化隔膜和门静脉束内或周围。肝肌成纤维细胞是细胞外基质物质的来源，包括I型胶原和多种成纤维生长因子，如转化生长因子-β和血管内皮生长因子。尽管由于缺乏适当的细胞标记物，尚未对单个肌成纤维细胞的功能进行详细的表征，但最近的谱系追踪技术显示，与肝星状细胞相比，源自门静脉成纤维细胞的肌成纤维细胞对各种类型的肝纤维化的贡献有限。此外，作为哺乳动物中的第四种球蛋白，细胞珠蛋白作为局部气体传感器，为星状细胞参与纤维化和癌变提供了新的视角，可能是通过其抗氧化特性，并且是区分源自星状细胞的肌成纤维细胞和来自门静脉成纤维细胞的肌成纤维细胞的有希望的新标记。
Myofibroblasts play important roles in inflammation, fibrosis and tumorigenesis in chronically inflamed liver. Liver myofibroblasts originate from hepatic stellate cells, portal fibroblasts or mesothelial cells, and they are localized in and around fibrotic septum and portal tracts. Liver myofibroblasts are the source of extracellular matrix materials, including type I collagen and multiple fibrogenic growth factors, such as transforming growth factor-β and vascular endothelial growth factor. Although a detailed characterization of the function of individual myofibroblasts has not been conducted, owing to the lack of appropriate cell markers, recent lineage-tracing technology has revealed the limited contribution of myofibroblasts that are derived from portal fibroblasts to various types of liver fibrosis, as compared with the contribution of hepatic stellate cells. In addition, cytoglobin, which is the fourth globin in mammals and function as a local gas sensor, provides a new perspective on the involvement of stellate cells in fibrosis and carcinogenesis, possibly through its anti-oxidative properties and is a promising new marker that discriminates between myofibroblasts derived from stellate cells and those from portal fibroblasts.