Comparison of inhibition of bone resorption and escape with calcitonin and dibutyryl 3',5' cyclic adenosine monophosphate.
Comparison of inhibition of bone resorption and escape with calcitonin and dibutyryl 3',5' cyclic adenosine monophosphate.
复制标题
降钙素和二丁酰3,5环单磷酸腺苷抑制骨吸收和逃逸的比较。
DOI：
10.1080/07435808109065983
复制
发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Raisz,LG
中科院分区：
文献类型：
--
作者：
McLeod,JF;Raisz,LG
甲状旁腺素（PTH）和降钙素（CT）均可增加器官培养胎鼠骨中环3′，5′-磷酸腺苷（cAMP）的含量。此外，二丁酰cAMP（dbcAMP）可以刺激和阻止45 Ca从这样的骨释放，这取决于剂量和实验条件，在这项研究中，我们比较了dbcAMP和CT对PTH预处理的骨的影响。这两种化合物产生短暂的抑制骨吸收，然后逃逸。逃避dbcAMP是独立的前列腺素的合成，因为它发生在存在和不存在的吲哚美辛，前列腺素环氧合酶抑制剂。
Both parathyroid hormone (PTH) and calcitonin (CT) can increase the concentration of cyclic 3′, 5′ adenosine monophosphate (cAMP) in fetal rat bone in organ culture. Moreover, dibutyryl cAMP (dbcAMP) can both stimulate and inhibit45Ca release from such bones depending on dose and experimental conditions, in this study we compared dbcAMP and CT for their effects on bones pretreated with PTH. Both compounds produced transient inhibition of bone resorption followed by escape. Escape from dbcAMP was independent of prostaglandin synthesis, since it occurred both in the presence and absence of indomethacin, a prostaglandin cyclo-oxygenase inhibitor.