Mechanical and histological evaluation of a PMMA-based bone cement modified with gamma-methacryloxypropyltrimethoxysilane and calcium acetate.
Mechanical and histological evaluation of a PMMA-based bone cement modified with gamma-methacryloxypropyltrimethoxysilane and calcium acetate.
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DOI：
10.1016/j.biomaterials.2006.03.002
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发表时间：
2006-07
期刊：
影响因子：
14
通讯作者：
T. Tsukeoka;Masahiko Suzuki;C. Ohtsuki;A. Sugino;Y. Tsuneizumi;J. Miyagi;K. Kuramoto;H. Moriya
中科院分区：
文献类型：
--
作者：
T. Tsukeoka;Masahiko Suzuki;C. Ohtsuki;A. Sugino;Y. Tsuneizumi;J. Miyagi;K. Kuramoto;H. Moriya
聚甲基丙烯酸甲酯（PMMA）骨水泥广泛应用于骨科手术中的假肢固定；然而，骨和骨水泥之间的界面是一个薄弱区。我们通过用γ-甲基丙烯酰氧基丙基三甲氧基硅烷（MPS）和醋酸钙进行改性，开发了一种生物活性PMMA水泥。本研究的目的是比较改良骨水泥与传统骨水泥的操作、机械和组织学特性。修改后的样本在骨和植入物之间表现出更高的结合强度。组织学观察和微焦X射线计算机断层扫描（micro-CT）图像表明，改性骨水泥具有传统PMMA骨水泥所缺乏的骨传导性。研究发现，这种修改可以有效地实现 PMMA 骨水泥的骨传导，从而在植入后提供长期稳定的固定。
Polymethylmethacrylate (PMMA) bone cement is widely used for prosthetic fixation in orthopaedic surgery; however, the interface between bone and cement is a weak zone. We developed a bioactive PMMA cement through modification with γ-methacryloxypropyltrimethoxysilane (MPS) and calcium acetate. The purpose of this study was to compare the handling, mechanical and histological properties of the modified bone cement with those of the conventional cement. The modified specimens exhibited higher bonding strength between bone and implant. Histological observation and micro-focus X-ray computed tomogram (micro-CT) images showed that the modified cement exhibited osteoconduction, which the conventional PMMA bone cement lacked. The modification was found to be effective in enabling osteoconduction with PMMA bone cement, thus providing stable fixation for a long period after implantation.