Clinical predictive value of in vitro anticancer drug sensitivity test for the therapeutic effect of adjuvant chemotherapy in patients with stage II–III colorectal cancer
Clinical predictive value of in vitro anticancer drug sensitivity test for the therapeutic effect of adjuvant chemotherapy in patients with stage II–III colorectal cancer
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体外抗癌药敏试验对II~III期结直肠癌辅助化疗疗效的临床预测价值
DOI：
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发表时间：
2013
影响因子：
1.2
通讯作者：
T. Tani
中科院分区：
文献类型：
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作者：
E. Mekata;H. Sonoda;Tomoharu Shimizu;Takeshi Tatsuta;T. Yamaguchi;Y. Endo;T. Tani
结直肠根治性手术后辅助化疗疗效的临床有用预测因子仍有待确定。在本研究中，我们研究了胶原凝胶液滴包埋培养药物敏感性试验（CD-DST）作为预测II-III期结直肠癌患者对5-氟尿嘧啶（5-FU）辅助化疗的治疗反应的临床效用。使用从189名患者手术获得的肿瘤样本进行CD-DST。比较高敏感组（高组）、低敏感组（低组）和未接受化疗组[CTx（-）组]的5-FU方案的疗效。189例患者中，151例（79.9%）成功进行了CD-DST，其中87例术后接受了以5-FU为基础的辅助化疗。这87例患者中的27例（31.0%）被归类为高水平组，其余60例（69.0%）被归类为低水平组。高剂量组的5年无复发生存率（RFS）显著高于低剂量组和CTx（-）组。低CTx组和CTx（-）组之间的5年RFS无差异。总之，CD-DST似乎有助于预测II-III期结直肠癌患者对基于5-FU的辅助化疗的治疗反应。
Clinically useful predictors of the efficacy of adjuvant chemotherapy following curative colorectal surgery remain to be determined. In the present study, we investigated the clinical utility of the collagen gel droplet-embedded culture drug sensitivity test (CD-DST) as a predictor of the therapeutic response to 5-fluorouracil (5-FU)-based adjuvant chemo-therapy in patients with stage II–III colorectal cancer. CD-DST was conducted using tumor samples surgically obtained from 189 patients. The therapeutic effect of 5-FU-based regimens between high (high-group) and low (low-group) sensitivity groups and a group that did not receive chemotherapy [CTx(-) group] was compared. CD-DST was successfully performed in 151 out of the 189 patients (79.9%), 87 of whom received 5-FU-based adjuvant chemotherapy after surgery. Twenty-seven of these 87 patients (31.0%) were classified as the high-group and the remaining 60 (69.0%) as the low-group. The 5-year recurrence-free survival (RFS) in the high-group was significantly higher compared to that in the low- and the CTx(-) groups. No differences in the 5-year RFS were observed between the low- and CTx(-) groups. In conclusion, CD-DST appears to be useful for predicting the therapeutic response to 5-FU-based adjuvant chemotherapy in patients with stage II-III colorectal cancer.
影响因子：
45.3
作者：
Kuebler, J. Philip;Wieand, H. Samuel;Wolmark, Norman
通讯作者：
Wolmark, Norman
影响因子：
158.5
作者：
Watanabe, T;Wu, T;Hamilton, SR
通讯作者：
Hamilton, SR
影响因子：
45.3
作者：
Sargent, Daniel J.;Marsoni, Silvia;Gallinger, Steven
通讯作者：
Gallinger, Steven