Bone marrow fat and the decline of B lymphopoiesis in rabbits.
Bone marrow fat and the decline of B lymphopoiesis in rabbits.
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DOI：
10.1016/j.dci.2015.11.003
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发表时间：
2016-05
影响因子：
2.9
通讯作者：
Knight KL
中科院分区：
文献类型：
--
作者：
Kennedy DE;Witte PL;Knight KL
B淋巴细胞生成是产生多种幼稚B细胞库所必需的，所述幼稚B细胞能够在对病原体和疫苗接种的免疫应答期间对广谱抗原应答。多年来，兔已被用于产生高亲和力的单克隆和多克隆抗体。在兔子身上产生的特异性抗体极大地促进了科学发现，但兔子B细胞发育的独特品质却没有得到充分的重视。与人类和小鼠中B淋巴细胞生成在中晚期下降不同，兔子中的B淋巴细胞生成在生命早期（2-4个月大之间）停止。本文综述了兔B细胞发育的早期丧失以及骨髓微环境对这一过程的贡献。我们还提出了未来在这一领域的研究方向，并讨论了如何兔可以作为一个模型，以了解在人类晚年发生的B淋巴细胞生成的下降。这些研究对于开发靶向预防和/或逆转老年人B淋巴细胞生成下降的治疗方法以及增强感染或疫苗接种后的免疫力和抗体应答将是重要的。
B lymphopoiesis is necessary to generate a diverse pool of naïve B cells that are able to respond to a broad spectrum of antigens during immune responses to pathogens and to vaccination. Rabbits have been utilized for many years to generate high affinity monoclonal and polyclonal antibodies. Specific antibodies generated in rabbits have greatly advanced scientific discoveries, but the unique qualities of rabbit B cell development have been underappreciated. Unlike in humans and mice, where B lymphopoiesis declines in mid to late life, B lymphopoiesis in rabbits arrests early in life, between 2–4 months of age. This review focuses on the early loss of B cell development in rabbits and the contribution of the bone marrow microenvironment to this process. We also propose directions for future research in this area, and discuss how the rabbit can be used as a model to understand the decline of B lymphopoiesis that occurs in humans late in life. Such studies will be important for developing therapeutics targeted to prevent and/or reverse declining B lymphopoiesis in the elderly, as well as boosting immunity and antibody responses after infection or vaccination.