Translational regulation during stage transitions in malaria parasites.
Translational regulation during stage transitions in malaria parasites.
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DOI：
10.1111/nyas.12573
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发表时间：
2015-04
影响因子：
5.2
通讯作者：
Miao J
中科院分区：
文献类型：
--
作者：
Cui L;Lindner S;Miao J
疟疾寄生虫复杂的生命周期涉及脊椎动物宿主和蚊子载体，并且翻译调节在两个过渡阶段（配子体和子孢子）的发育事件中起着突出的作用。翻译调节以全局和转录物特异性方式执行。疟原虫在蚊子唾液腺中的子孢子发育的潜伏期期间使用涉及eIF2α磷酸化的保守机制来抑制整体蛋白质合成。转录特异性的翻译调控是通过RNA结合蛋白（RBP）的网络来实现的，其中Dhh1 RNA解旋酶DOZI和Puf家族RBP是迄今为止在疟原虫中研究得最好的。虽然DOZI复合物定义了一种新的P颗粒，具有保护某些配子体mRNA免受降解的作用，但Puf蛋白似乎抑制配子体和子孢子中mRNA的表达。这些例子强调了疟原虫发育中翻译调控的重要性。
The complicated life cycle of the malaria parasite involves a vertebrate host and a mosquito vector, and translational regulation plays a prominent role in orchestrating the developmental events in the two transition stages, gametocytes and sporozoites. Translational regulation is executed in both global and transcript-specific manners. Plasmodium uses a conserved mechanism involving phosphorylation of eIF2α to repress global protein synthesis during the latent period of sporozoite development in the mosquito salivary glands. Transcript-specific translational regulation is achieved by a network of RNA-binding proteins (RBPs), among which the Dhh1 RNA helicase DOZI and Puf family RBPs are by far the best studied in Plasmodium. While the DOZI complex defines a new P granule with a role in protecting certain gametocyte mRNAs from degradation, the Puf proteins appear to repress expression of mRNAs in both gametocytes and sporozoites. These examples underscore the significance of translational regulation in Plasmodium development.
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影响因子：
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作者：
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