Background noise - The experience of chemotherapy-induced peripheral neuropathy
Background noise - The experience of chemotherapy-induced peripheral neuropathy
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DOI：
10.1097/01.nnr.0000289503.22414.79
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发表时间：
2007-09-01
期刊：
影响因子：
2.5
通讯作者：
Bakitas, Marie A.
中科院分区：
文献类型：
--
作者：
Bakitas, Marie A.
背景每年被诊断患有癌症的130万人中有相当一部分接受神经毒性化疗，这可能会产生令人痛苦的症状和功能能力的变化。目的：描述化疗引起的周围神经病变（chemotherapy-induced peripheral neuropathy，CIPN）患者的症状体验及其对日常生活的影响。采访从国家癌症研究所指定的农村综合癌症中心招募了28名参与者。访谈录了音，逐字转录，并输入到Atlas.ti软件。结果：研究对象在年龄（46-81岁）、癌症类型、确诊时间（3-198个月）、神经病变严重程度、接受神经毒性化疗药物等方面具有多样性。内容分析产生了丰富的，厚厚的描述CIPN症状和功能能力和日常生活的症状的影响。进一步的解释性分析通过一个总体隐喻、背景噪音和四个主要主题提供了对症状体验的描述：（a）意识到;（B）学习新歌词;（c）功能、情感和社会角色杂音;（d）学习与之共存。参与者描述了由于CIPN造成的显著的身体限制、情绪困扰和社会角色障碍。患有CIPN会导致不同的症状模式和程度的身体症状困扰，从轻度到重度，情绪困扰，功能能力的改变和社会角色障碍。需要综合的临床和研究措施来评估CIPN对日常生活的全方位影响。
Background. A substantial portion of the 1.3 million persons diagnosed annually with cancer receive neurotoxic chemotherapy that may produce distressful symptoms and changes in functional ability. However, little is known about the symptom experience and daily life effects of chemotherapy-induced peripheral neuropathy (CIPN).Objective: To describe the CIPN symptom experience and the influence of symptoms on everyday life.Methods: This was a qualitative, exploratory, interpretive, descriptive study with semistructured. interviews. A purposive sample of 28 participants was recruited from a rural National Cancer Institute-designated comprehensive cancer center. Interviews were audiotaped, transcribed verbatim, and imported into Atlas.ti software. Content analysis and constant comparative method were used to analyze the data.Results: Participants represented diversity in age (46-81 years), cancer type, time since diagnosis (3-198 months), neuropathy severity, and neurotoxic chemotherapy agents received. Content analysis yielded a rich, thick description of CIPN symptoms and the influence of the symptoms on functional ability and everyday life. Further interpretive analysis provided a description of the symptom experience through an overarching metaphor, Background Noise, and four major themes: (a) Becoming Aware; (b) Learning New Lyrics; (c) Functional, Emotional, and Social Role Cacophony; and (d) Learning to Live With It. Participants described significant physical limitations, emotional distress, and social role impairments due to CIPN.Conclusions: Having CIPN results in diverse symptom patterns and degrees of physical symptom distress from mild to severe, emotional distress, alterations in functional ability, and social role impairment. Comprehensive clinical and research measures are needed to assess the full spectrum of CIPN effects on everyday life.