The compound factor of the 10B(n,alpha)7Li reaction from borocaptate sodium and the relative biological effectiveness of recoil protons for induction of brain damage in boron neutron capture therapy.
The compound factor of the 10B(n,alpha)7Li reaction from borocaptate sodium and the relative biological effectiveness of recoil protons for induction of brain damage in boron neutron capture therapy.
复制标题
硼醇钠 10B(n,α)7Li 反应的复合因素以及反冲质子在硼中子俘获疗法中诱导脑损伤的相对生物有效性。
作者：
D. Gabel;K. Philipp;F. Wheeler;R. Huiskamp
为了使硼中子俘获治疗的临床试验对患者安全，有必要知道辐射组分的相对生物学有效性（RBE）和所使用的硼载体的复合因子。在这里，一种方法来确定反冲质子的RBE和化合物的复合因子从体内实验与不同浓度的硼。该方法使用这两个参数的所有实验数据的同时拟合。该方法适用于在荷兰佩滕的高通量反应堆中进行的犬健康组织耐受性研究。发现超热中子束中存在的中子产生的反冲质子的RBE [连同来自14 N（n，p）14 C反应的质子的RBE]对于诱导严重神经症状的RBE为3.93+/-0.43（95%置信限3.06-4.79），以及2.33+/-0.14（2.04-2.61），用于诱导磁共振成像可检测到的变化。使用严重神经症状作为终点，脑组织中Na 2B 12 H11 SH的复合因子确定为0.37+/-0.06（95%置信限0.24-0.50）。对于磁共振成像可检测到的变化，发现该值为0.65+/-0.04（0.58-0.73）。
To make clinical trials of boron neutron capture therapy safe for patients, it is necessary to know the relative biological effectiveness (RBE) of the radiation components and the compound factor of the boron carrier to be used. Here a method is derived to determine the RBE of recoil protons and the compound factor of compounds from in vivo experiments with different concentrations of boron. The method uses a simultaneous fit of both these parameters to all experimental data. This method is applied to the studies of tolerance of healthy tissue in dogs at the High Flux Reactor in Petten, The Netherlands. The RBE for the recoil protons generated by the neutrons present in the epithermal neutron beam [together with the RBE of the protons from the 14N(n,p)14C reaction] for induction of severe neurological symptoms was found to be 3.93+/-0.43 (95% confidence limits 3.06-4.79), and 2.33+/-0.14 (2.04-2.61) for induction of changes detectable by magnetic resonance imaging. The compound factor for Na2B12H11SH in brain tissue, using severe neurological symptoms as end point, was determined to be 0.37+/-0.06 (95% confidence limits 0.24-0.50). For changes detectable by magnetic resonance imaging, the value was found to be 0.65+/-0.04 (0.58-0.73).
犬脑的计算机断层扫描分析：半脑 X 射线照射的影响。
影响因子：
3.4
作者：
Fike,JR;Cann,CE;Davis,RL;Borcich,JK;Phillips,TL;Russell,LB
通讯作者：
Russell,LB