Prediction mechanisms in motor and auditory areas and their role in sound perception and language understanding
Prediction mechanisms in motor and auditory areas and their role in sound perception and language understanding
复制标题
DOI：
10.1016/j.neuroimage.2019.05.071
复制
发表时间：
2019-10-01
期刊：
影响因子：
5.7
通讯作者：
Pulvermueller, Friedemann
中科院分区：
文献类型：
--
作者：
Grisoni, Luigi;Mohr, Bettina;Pulvermueller, Friedemann
预期刺激的意义在它出现之前就已经在大脑活动中显现了吗？虽然预测编码理论认为预期活动对于理解大脑功能至关重要，但很少有研究探讨神经生理学上的明显语义预测。在这里，我们报告了在动作（即口哨和拍手）和非动作（即纯音，水滴）声音开始之前的预测负向电位。这些预测电位（PP）索引的意义的动作相关的声音。根据声音刺激的身体部位关系，神经源在背侧或腹侧运动区相对更突出。相比之下，无意义的声音（纯音）激活了听觉皮层附近颞区的预测源;复杂的环境声音引起了广泛分布在头皮上的预期积极性。我们还发现了一个系统的预测活动和失配负性（MMN）的反应，意想不到的有意义的话，这是罕见的异常刺激之间频繁重复的声音。这种偏差引起的潜在索引动作声音和动作相关的词和语义不匹配（预测错误）之间的语义启动。这些结果表明，知觉/语义预测和匹配机制之间的声音和文字的处理系统的联系。
Is the meaning of an expected stimulus manifest in brain activity even before it appears? Although theories of predictive coding see anticipatory activity as crucial for the understanding of brain function, few studies have explored neurophysiologically manifest semantic predictions. Here, we report predictive negative-going potentials before the onset of action (i.e. whistle and hand clap) and non-action (i.e. pure tone, water drop) sounds. These prediction potentials (PP) indexed the meaning of action-related sounds. Dependent on the body-part-relationship of sound stimuli, neural sources were relatively more prominent in dorsal or ventral motor areas. In contrast, meaningless sounds (pure tones) activated predictive sources in temporal areas close to the auditory cortex; complex environmental sounds induced an anticipatory positivity broadly distributed over the scalp. We also found a systematic relationship between predictive activity and a Mismatch Negativity (MMN) like response to unexpected meaningful words which were presented as rare deviant stimuli amongst frequently repeated sounds. This deviant-elicited potential indexed semantic priming between action sounds and action-related words and semantic mismatch (prediction error). These results suggest a systematic link between perceptual/semantic prediction and matching mechanisms in the processing of sounds and words.