Genetic effects on physical activity: Results from the Swedish twin registry
Genetic effects on physical activity: Results from the Swedish twin registry
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DOI：
10.1249/01.mss.0000228941.17034.c1
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发表时间：
2006-08-01
期刊：
影响因子：
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通讯作者：
Ahlbom, Anders
中科院分区：
文献类型：
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作者：
Carlsson, Sofia;Andersson, Tomas;Ahlbom, Anders
目的：本研究的目的是利用瑞典双胞胎登记处的数据调查遗传对闲暇时间体力活动的影响。方法：我们调查了13,362对14-46岁的双胞胎（5334对同卵双胞胎和8028对异卵双胞胎）。通过问卷调查获得闲暇体育活动的信息。分别计算男性、女性、同卵双胞胎和异卵双胞胎的体力活动相关性和比值比。结构方程模型被用来估计遗传效应以及共同和非共享的环境因素对休闲时间体力活动的贡献。结果：大约三分之一的双胞胎报告说，他们经常锻炼（26%的女性和39%的男性）。同卵双胞胎的体力活动的相关性是异卵双胞胎的两倍，这表明遗传效应的存在。由于遗传导致的体力活动变化在男性中为57%（95%置信区间（CI）= 0.49-0.63），在女性中为50%（95% CI = 0.49-0.55）。与个体特有的环境因素的影响相比，普通环境对体力活动的影响非常小。结论：我们的研究确立了遗传是成年男性和女性体力活动个体差异背后的重要组成部分。这可能是难以说服人们采取积极生活方式的原因之一。尽管如此，这项研究表明，个体特有的环境因素对身体活动有很大的影响。
Purpose: The aim of this study was to investigate the genetic effects on leisure-time physical activity using data from the Swedish Twin Registry. Methods: We investigated 13,362 twin pairs (5334 monozygotic and 8028 dizygotic pairs) aged 14-46 yr. Information on leisure-time physical activity was obtained by questionnaire. Correlations and odds ratios of physical activity were calculated for males, females, and monozygotic and dizygotic twins, respectively. Structural equation modeling was used to estimate the contribution of genetic effects as well as common and nonshared environmental factors on leisure-time physical activity. Results: About one third of the twins reported that they exercised regularly (26% in females and 39% in males). The correlations of physical activity were twice as high in monozygotic compared with dizygotic twins, suggesting the presence of genetic effects. The variation in physical activity due to heritage was 57% (95% confidence interval (CI) = 0.49-0.63) in males and 50% (95% Cl = 0.49-0.55) in females. The common environmental influence on physical activity was very small compared with the influence from environmental factors unique to the individual. Conclusions: Our study establishes heredity as an important component behind individual differences in physical activity in adult men and women. This may be one reason behind difficulties in convincing people to adopt an active lifestyle. Still, this study shows that there is a substantial influence on physical activity from environmental factors unique to the individual.