Pathophysiologic and therapeutic importance of tissue ACE:: A consensus report
Pathophysiologic and therapeutic importance of tissue ACE:: A consensus report
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DOI：
10.1023/a:1015709617405
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发表时间：
2002-03-01
影响因子：
3.4
通讯作者：
Weber, M
中科院分区：
文献类型：
--
作者：
Dzau, VJ;Bernstein, K;Weber, M
血管紧张素转换酶 (ACE) 的激活和血管紧张素 II 的从头产生通过直接的病理组织效应（包括血管重塑和炎症）以及对一氧化氮生物利用度及其后果的间接作用，导致心血管疾病。内皮细胞在血管功能和结构中发挥着关键作用。因此，ACE 主要定位于内皮细胞，对血管疾病（例如冠状动脉疾病）的病理学具有重要意义。大量实验研究和临床试验支持人们逐渐认识到组织 ACE 是一个重要的治疗靶点，并且抑制它可以恢复内皮功能或预防内皮功能障碍。这些效果超出了单纯降低血压所带来的效果；因此，ACE抑制剂可能通过直接组织作用发挥其作用的重要部分。药理学研究表明，虽然 ACE 抑制剂可能因其与组织 ACE 的结合亲和力而有所不同，但其临床意义仍有待确定。
Angiotensin-converting enzyme (ACE) activation and the de novo production of angiotensin II contribute to cardiovascular disease through direct pathological tissue effects, including vascular remodeling and inflammation, as well as indirect action on nitric oxide bioavailability and its consequences. The endothelium plays a pivotal role in both vascular function and structure; thus, the predominant localization of ACE to the endothelium has implications for the pathobiology of vascular disease, such as coronary artery disease. Numerous experimental studies and clinical trials support the emerging realization that tissue ACE is a vital therapeutic target, and that its inhibition may restore endothelial function or prevent endothelial dysfunction. These effects exceed those attributable to blood pressure reduction alone; hence, ACE inhibitors may exert an important part of their effects through direct tissue action. Pharmacologic studies show that while ACE inhibitors may differ according to their binding affinity for tissue ACE the clinical significance remains to be determined.