Signaling Pathways in Liver Diseases
Signaling Pathways in Liver Diseases
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DOI：
10.1007/978-3-642-00150-5
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
J. Dufour;P. Clavien;C. Trautwein;R. Graf
中科院分区：
文献类型：
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作者：
J. Dufour;P. Clavien;C. Trautwein;R. Graf
肝病诊断和治疗方法的最新进展将肝病学推向了新的领域。脂肪变性和肝硬化肝脏接受复杂的治疗策略的频率越来越高，这对肝脏外科医生和肝病学家来说是一个挑战，他们需要了解在这些情况下发挥作用的分子机制。理解参与肝再生、肝细胞凋亡和缺血/再灌注损伤的信号通路至关重要。本书是促进文献阅读和试验规划的信息来源。转化医学意味着对新型治疗策略的分子靶点的了解。我们的目标是促进研究，促进实验室、临床病房和手术室之间的交流。这种包括分子和细胞事件的全面见解将为改善复杂肝病的药理学和外科干预措施铺平道路。
Recent advances in diagnostic and therapeutic approaches to liver disease have carried hepatology to new frontiers. The increasing frequency with which steatotic and cirrhotic livers undergo complex curative treatment strategies is a challenge to liver surgeons and hepatologists, who need to understand the molecular mechanisms at play in these situations. Comprehension of the signaling pathways participating in liver regeneration, hepatocellular apoptosis, and ischemia/reperfusion injury is essential. This book serves as a source of information to facilitate the reading of the literature and the planning of trials. Translational medicine implies knowledge of the molecular targets of novel therapeutic strategies. It is our goal to stimulate research that leads to exchanges between the laboratory, the clinical ward, and the operating room. Such a comprehensive insight including molecular and cellular events will pave the way for improvement of pharmacological and surgical interventions in complex liver disease.