Bioactivity of Fe2O3-containing CaO-SiO2 glasses: in vitro evaluation
Bioactivity of Fe2O3-containing CaO-SiO2 glasses: in vitro evaluation
复制标题
含 Fe2O3 CaO-SiO2 玻璃的生物活性：体外评价
DOI：
10.1007/bf00122273
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
T. Yamamuro
中科院分区：
文献类型：
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作者：
Y. Ebisawa;T. Kokubo;K. Ohura;T. Yamamuro
为了揭示获得生物活性和亚铁磁玻璃陶瓷作为热种子用于癌症热治疗的条件，通过在离子浓度几乎等于人血浆中的离子浓度的模拟体液中检查玻璃表面上磷灰石的形成，研究了添加剂对 Fe2O3-CaO-SiO2 玻璃生物活性的影响。 3Fe2O3、100CaO·SiO2(重量比)玻璃在流体中表面不形成磷灰石层，但相同成分的玻璃添加3Na2O、B2O3和/或P2O5(重量比)则形成磷灰石层。这表明添加Na2O、B2O3和/或P2O5的含Fe2O3的CaO-SiO2玻璃可以得到具有生物活性和亚铁磁性的微晶玻璃。含有添加剂的玻璃表面上磷灰石的形成可以用钙离子和硅酸根离子从玻璃中的溶解来解释。
In order to reveal conditions for obtaining bioactive and ferrimagnetic glass-ceramics useful as thermoseeds for hyperthermia treatment of cancer, the effects of additives on the bioactivity of an Fe2O3-CaO-SiO2glass were investigated by examining apatite formation on the surfaces of the glasses in a simulated body fluid with ion concentrations nearly equal to those in human blood plasma. A 3Fe2O3, 100CaO · SiO2(in weight ratio) glass did not form an apatite layer on its surface in the fluid, but glasses of the same compositions with 3Na2O, B2O3and/or P2O5added (in weight ratio) formed an apatite layer. This indicates that bioactive and ferrimagnetic glass-ceramics could be obtained from Fe2O3-containing CaO-SiO2glasses with Na2O, B2O3and/or P2O5added. Apatite formation on the surfaces of the glasses with the additives are interpreted in terms of the dissolution of the calcium and silicate ions from the glasses.