Toll-like receptors are key players in neurodegeneration.
Toll-like receptors are key players in neurodegeneration.
复制标题
DOI：
10.1016/j.intimp.2011.05.006
复制
发表时间：
2011-10
影响因子：
5.6
通讯作者：
Iribarren P
中科院分区：
文献类型：
--
作者：
Arroyo DS;Soria JA;Gaviglio EA;Rodriguez-Galan MC;Iribarren P
先天免疫反应的激活是通过模式识别受体 (PPR) 的参与启动的，例如 Toll 样受体 (TLR)。这些受体在外周白细胞和中枢神经系统 (CNS) 的许多细胞类型中表达。 CNS中TLRs的表达主要在星形胶质细胞和小胶质细胞中进行研究。然而，新的证据表明这些受体可能在神经元稳态中发挥重要作用。 CNS 中 TLR 的表达是可变的，可以受到多种因素的调节，包括促炎分子，这些分子在神经退行性疾病中升高，可以增加 CNS 细胞中 TLR 的表达。此外，TLR 的激活会诱导促炎细胞因子的释放。因此，TLRs已被证明在神经退行性疾病的多个方面发挥作用。在这里，我们将讨论最近文献中报道的有关 TLR 参与神经退行性疾病的结果。
The activation of innate immune response is initiated by engagement of pattern-recognition receptors (PPRs), such as Toll-like receptors (TLRs). These receptors are expressed in peripheral leukocytes and in many cell types in the central nervous system (CNS). The expression of TLRs in CNS was mainly studied in astrocytes and microglial cells. However, new evidence indicates that these receptors may play an important role in neuronal homeostasis. The expression of TLRs in the CNS is variable and can be modulated by multiple factors, including pro-inflammatory molecules, which are elevated in neurodegenerative diseases and can increase the expression of TLRs in CNS cells. Moreover, activation of TLRs induces the release of pro-inflammatory cytokines. Therefore, TLRs have been shown to play a role in several aspects of neurodegenerative diseases. Here we will discuss results reported in the recent literature concerning the participation of TLRs in neurodegenerative diseases.
登录
查看更多内容
影响因子：
15.1
作者：
Frank-Cannon TC;Alto LT;McAlpine FE;Tansey MG
通讯作者：
Tansey MG
影响因子：
5.3
作者：
Cameron, Jill S.;Alexopoulou, Lena;Vartanian, Timothy
通讯作者：
Vartanian, Timothy
影响因子：
3.3
作者：
Gandhi R;Laroni A;Weiner HL
通讯作者：
Weiner HL
DOI：
10.1038/nri2587
发表时间：
2009-08
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.3
作者：
Chakravarty, S;Herkenham, M
通讯作者：
Herkenham, M