SEMINAL RNASE - A UNIQUE MEMBER OF THE RIBONUCLEASE SUPERFAMILY
SEMINAL RNASE - A UNIQUE MEMBER OF THE RIBONUCLEASE SUPERFAMILY
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DOI：
10.1016/0968-0004(91)90042-t
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发表时间：
1991-03-01
影响因子：
13.8
通讯作者：
PARENTE, A
中科院分区：
文献类型：
--
作者：
DALESSIO, G;DIDONATO, A;PARENTE, A
牛精液中发现的核糖核酸酶，虽然是哺乳动物核糖核酸酶超家族的成员，但具有一些不寻常的特性。除了其独特的结构和酶学性质外，它还具有抗精子、抗肿瘤和免疫抑制活性。 种子RNA酶属于RNA酶的一个有趣的组，RISBASES（具有特殊的，即非催化的生物作用的核糖核酸酶），其其他成员包括血管生成素、选择性神经毒性RNA酶、凝集素和来自开花植物的自交不亲和因子。
The RNase found in bull semen, although a member of the mammalian superfamily of ribonucleases, possesses some unusual properties. Besides its unique structure and enzymic properties, it displays antispermatogenic, antitumor and immunosuppressive activities. Seminal RNase belongs to an interesting group of RNases, the RISBASES (RIbonucleases with Special, i.e. non catalytic, Biological Actions) other members of which include angiogenin, selectively neurotoxic RNases, a lectin and the self-incompatibility factors from a flowering plant.