Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems
Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems
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DOI：
10.1093/nar/29.1.346
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发表时间：
2001-01-01
影响因子：
14.9
通讯作者：
Cohen, FE
中科院分区：
文献类型：
--
作者：
Horn, F;Vriend, G;Cohen, FE
每天进入数据库和实验文献的基因组和蛋白质组数据的数量超过了实验科学家的能力。虽然来自自动化策展工作的通用数据库是有用的，但大多数生物科学家倾向于关注一类或一类分子及其生物学影响。因此，需要分子类别特异性或其他专门的数据库。这种数据库收集和组织围绕单个主题或一类分子的数据，如果管理良好，这种系统是非常有用的，因为它们允许实验科学家从单一来源获得与他们的需求最相关的大部分可用数据。我们参与了两个这样的数据库的开发，具有实质性的药理学相关性。这些是GPCRDB和NucleaRDB信息系统，分别收集和传播与G蛋白偶联受体和核内激素受体相关的数据。GPCRDB是一个试点项目，旨在建立一个能够处理高度异质性数据的通用分子类别特定数据库。GPCRDB项目的第一个版本已经完成，成千上万的科学家经常使用它。NucleaRDB最近开始作为该技术推广概念的应用。GPCRDB可通过万维网http：//www.example.com和NucleaRDB www.receptors.org/NR/获得。www.gpcr.org/7tm/and
The amount of genomic and proteomic data that is entered each day into databases and the experimental literature is outstripping the ability of experimental scientists to keep pace. While generic databases derived from automated curation efforts are useful, most biological scientists tend to focus on a class or family of molecules and their biological impact. Consequently, there is a need for molecular class-specific or other specialized databases. Such databases collect arid organize data around a single topic or class of molecules, If curated well, such systems are extremely useful as they allow experimental scientists to obtain a large portion of the available data most relevant to their needs from a single source. We are involved in the development of two such databases with substantial pharmacological relevance. These are the GPCRDB and NucleaRDB information systems, which collect and disseminate data related to G protein-coupled receptors and intranuclear hormone receptors, respectively. The GPCRDB was a pilot project aimed at building a generic molecular class-specific database capable of dealing with highly heterogeneous data. A first version of the GPCRDB project has been completed and it is routinely used by thousands of scientists. The NucleaRDB was started recently as an application of the concept for the generalization of this technology. The GPCRDB is available via the WWW at http:// www.gpcr.org/7tm/and the NucleaRDB at http:// www.receptors.org/NR/.