Relationship between leptin, adiponectin, bone mineral density, and measures of adiposity among pre-menopausal Hispanic and Caucasian women.
Relationship between leptin, adiponectin, bone mineral density, and measures of adiposity among pre-menopausal Hispanic and Caucasian women.
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DOI：
10.3109/07435800.2010.496090
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发表时间：
2010
影响因子：
2.1
通讯作者：
Thompson DL
中科院分区：
文献类型：
--
作者：
King GA;Deemer SE;Thompson DL
本研究的目的是探讨绝经前，中年西班牙裔和白人妇女空腹血清瘦素和脂联素水平与骨密度（BMD）和身体成分之间的关系。受试者（68名西班牙裔和36名白人）的BMD和骨矿物质含量通过双能X线吸收测定法测量，身体密度通过水密度测定法测量。血清瘦素测定采用酶免疫法，脂联素测定采用ELISA法。西班牙裔女性的瘦素、骨密度和脂肪量（FM）显著高于白人女性，脂联素显著低于白人女性。西班牙裔或白人女性瘦素与骨密度无显著相关性;仅白人女性脂联素与骨密度呈负相关（p = 0.01）。在西班牙裔和白人女性中，瘦体重和脂联素最能解释BMD的差异（r2 = 0.25，p < 0.001）。这些数据表明，绝经前，中年西班牙裔和高加索妇女瘦素和BMD之间没有显着的关系，和脂联素和BMD在高加索妇女显着的负相关。脂肪细胞因子在骨密度调节中的作用仍不确定，可能因种族而异。
The purpose of this study was to examine the relationship between fasting serum leptin and adiponectin levels with bone mineral density (BMD) and body composition in pre-menopausal, middle-aged Hispanic and Caucasian women. Participants’ (68 Hispanic and 36 Caucasian) BMD and bone mineral content were measured by dual-energy X-ray absorptiometry, and body density was measured by hydrodensitometry. Serum leptin was determined by enzyme immunoassay and adiponectin by ELISA. Hispanic women had significantly higher leptin, BMD, and fat mass (FM), and lower adiponectin than Caucasian women. There was no significant correlation between leptin and BMD for Hispanic or Caucasian women; adiponectin was inversely correlated with BMD in Caucasian women only (p = 0.01). In both Hispanic and Caucasian women, lean body mass and adiponectin best explained the variance in BMD (r2 = 0.25, p < 0.001). These data demonstrate no significant relationship between leptin and BMD of pre-menopausal, middle-aged Hispanic and Caucasian women, and a significant inverse relationship between adiponectin and BMD in Caucasian women. The role of adipocytokines in the regulation of BMD remains inconclusive and may vary across ethnic groups.