Common and differential ventrolateral prefrontal activity during inhibition of hand and eye movements
Common and differential ventrolateral prefrontal activity during inhibition of hand and eye movements
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DOI：
10.1523/jneurosci.2837-07.2007
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发表时间：
2007-09-12
影响因子：
5.3
通讯作者：
Cai, Weidong
中科院分区：
文献类型：
--
作者：
Leung, Hoi-Chung;Cai, Weidong
下额叶皮层，特别是右半球的腹外侧前额叶皮层（VLPFC），被认为是行为认知控制的一般抑制机制。由于这一概念主要是基于对手动任务中反应抑制的研究，因此尚未在其他反应模式中得到验证。我们进行了一项功能性磁共振成像研究，以检查在同一受试者的手和眼抑制反应期间，VLPFC是否通常被激活。我们使用停止信号任务，一种相对纯粹的反应抑制测量，作为行为范例。12名受试者的结果显示，在手动和跳动反应的抑制过程中，左右尾侧VLPFC和运动前区吻侧的前岛都被激活。在VLPFC后部，两种反应模式的激活在很大程度上重叠，尽管沿背腹侧轴也发现了较弱的功能分化。其他区域，如内侧额上回（辅助运动前区/辅助视野）、背外侧前额叶皮层和顶叶下皮层在取消手和眼运动时也被激活。我们的研究结果表明，一个共同的VLPFC网络参与了反应抑制，尽管不同反应模式的特定控制可能在外侧前额皮质中部分分离。
The inferior frontal cortex, particularly the ventrolateral prefrontal cortex (VLPFC) in the right hemisphere, has been implicated to serve as a general inhibitory mechanism in the cognitive control of behavior. Because this notion was primarily based on studies of response inhibition in manual tasks, it has yet to be validated in other response modalities. We conducted a functional magnetic resonance imaging study to examine whether the VLPFC is commonly activated during inhibition of responses by hand and by eye within the same subjects. We used the stop-signal task, a relatively pure measure of response inhibition, as the behavioral paradigm. Results from 12 subjects showed that both the right and the left caudal VLPFC and anterior insula, rostral to the premotor area, are activated during inhibition of both manual and saccadic responses. Within the posterior VLPFC, activations overlapped to a significant extent across the two response modalities, although a weaker functionally differentiation was also found along the dorsoventral axis. Other areas such as medial superior frontal gyrus (pre-supplementary motor area/supplementary eye field), dorsolateral prefrontal cortex, and inferior parietal cortex were also activated during canceling both hand and eye movements. Our findings suggest that a common VLPFC network is involved in response inhibition, although the specific control of the different response modalities may be partially segregated within the lateral prefrontal cortex.