DEVELOPMENT, MORPHOLOGY, AND FUNCTION OF THE YOLK-SAC PLACENTA OF LABORATORY RODENTS
DEVELOPMENT, MORPHOLOGY, AND FUNCTION OF THE YOLK-SAC PLACENTA OF LABORATORY RODENTS
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DOI：
10.1002/tera.1420410403
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发表时间：
1990-04-01
期刊：
影响因子：
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通讯作者：
JOLLIE, WP
中科院分区：
文献类型：
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作者：
JOLLIE, WP
对常见实验室啮齿动物（即大鼠、小鼠、仓鼠、豚鼠和沙鼠）卵黄囊膜的异常结构和几种功能的现有知识进行回顾，可以更好地评估这种母胎交换系统在先天性异常实验中的重要性。啮齿动物卵黄囊胎盘内脏壁和壁壁的解剖结构，特别是每个壁与母体和其他胎儿组织的解剖关系，取决于这几个物种中卵黄囊的起源和随后的发育模式。因此，描述了啮齿动物卵黄囊的发育生物学。由于精细结构和解剖关系也在很大程度上决定了膜作为一个整体在吸收选定材料以进行细胞内消化或细胞易位和运输到发育胚胎时的功能，因此详细考虑卵黄囊的解剖结构。同样，由于现有证据强烈表明，致畸剂会扰乱控制卵黄囊胎盘系统在出生缺陷产生中的这几种功能的细胞机制，因此还考虑了膜的细胞生物学，即内吞作用和靶向/运输物质，要么在内脏卵黄囊母体表面的上皮内消化，要么作为卵黄囊膜转运穿过卵黄囊膜。整个。
A review of current knowledge of the unusual structure and several functions of the yolk‐sac membranes of common laboratory rodents, viz., rats, mice, hamsters, guinea pigs and gerbils, enables a better assessment of the significance of this maternofetal exchange system in the experimental production of congenital anomalies. The anatomy of both visceral and parietal walls of the rodent yolk‐sac placenta—specifically the anatomical relationships of each wall with maternal and with other fetal tissues—depends on the mode of origin and subsequent development of the yolk sac in these several species. Accordingly, the developmental biology of the rodent yolk sac is described. Since both fine structure and anatomical relationships also determine in large measure the functioning of the membrane as a whole in the absorption of selected materials either for intracellular digestion or for cellular translocation and transport to the developing embryo, the anatomy of the yolk sac is considered in detail. Similarly, since available evidence strongly suggests that teratogenic agents induce perturbations in the cellular mechanisms that control these several functions of the yolk‐sac placental system in the production of birth defects, additionally an account is given of the cell biology of the membrane, i.e., endocytosis and targeting/trafficking of materials either for digestion within the epithelium at the maternal surface of the visceral yolk sac or for translocation across the yolk‐sac membrane as a whole.