Ocular Demodicosis as a Potential Cause of Ocular Surface Inflammation.
Ocular Demodicosis as a Potential Cause of Ocular Surface Inflammation.
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DOI：
10.1097/ico.0000000000001361
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发表时间：
2017-11
期刊：
影响因子：
2.8
通讯作者：
Liang L
中科院分区：
文献类型：
--
作者：
Luo X;Li J;Chen C;Tseng S;Liang L
在不同种类的螨虫中，毛囊蠕形螨和短蠕形螨是唯一两种影响人眼的螨虫。由于蠕形螨病高度依赖于年龄，并且可以在无症状的成年人中发现，因此这些螨虫的致病性长期以来一直存在争议。在此，我们总结了我们的研究经验，包括我们最近关于蠕形螨感染作为眼部炎症疾病潜在原因的研究。具体来说，我们描述了蠕形螨病的发病机制，然后依次讨论了眼部蠕形螨病与睑缘炎、睑板腺疾病和角膜炎之间的关联和关系的研究结果。接下来是对蠕形螨病诊断的一些讨论，最后简要讨论了眼部蠕形螨病不同治疗方法的证据。总的来说，我们的研究表明眼部蠕形螨病与眼表炎症（如睑缘炎、霰粒肿、MGD 和角膜炎）之间存在很强的相关性。有必要进一步研究潜在的致病机制。
Among different species of mites, Demodex folliculorum and Demodex brevis are the only two that affect the human eye. Because demodicosis is highly age-dependent and can be found in asymptomatic adults, the pathogenicity of these mites has long been debated. Herein, we summarize our research experience including our most recent study regarding Demodex infestation as a potential cause of ocular inflammatory diseases. Specifically, we describe the pathogenesis of demodicosis and then discuss the results of work investigating the associations and relationships between ocular demodicosis and blepharitis, meibomian gland diseases, and keratitis, in turn. This is followed by some discussion of the diagnosis of demodicosis, and concludes with a brief discussion of the evidence for different treatments for ocular demodicosis. Collectively, our studies suggest a strong correlation between ocular demodicosis and ocular surface inflammatory conditions, such as blepharitis, chalazia, MGD, and keratitis. Further investigation of the underlying pathogenic mechanism is warranted.