The role of prefrontal catecholamines in attention and working memory.
The role of prefrontal catecholamines in attention and working memory.
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DOI：
10.3389/fncir.2014.00033
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发表时间：
2014
影响因子：
3.5
通讯作者：
Noudoost B
中科院分区：
文献类型：
--
作者：
Clark KL;Noudoost B
尽管在识别涉及精神疾病认知过程的大脑区域和神经化学系统方面取得了很大进展，但到目前为止，神经生物学家描述导致认知功能的事件链的细节水平非常低。人们对了解认知功能的浓厚兴趣，很大程度上是因为希望有可能在神经元和神经回路的水平上理解这些复杂的功能。在这里，我们回顾了关于前额叶皮质(PFC)中儿茶酚胺水平的调节如何改变认知功能(特别是注意力和工作记忆)的神经元和行为相关的文献的现状。
While much progress has been made in identifying the brain regions and neurochemical systems involved in the cognitive processes disrupted in mental illnesses, to date, the level of detail at which neurobiologists can describe the chain of events giving rise to cognitive functions is very rudimentary. Much of the intense interest in understanding cognitive functions is motivated by the hope that it might be possible to understand these complex functions at the level of neurons and neural circuits. Here, we review the current state of the literature regarding how modulations in catecholamine levels within the prefrontal cortex (PFC) alter the neuronal and behavioral correlates of cognitive functions, particularly attention and working memory.