Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review.
Multi-Mechanistic Approaches to the Treatment of Traumatic Brain Injury: A Review.
复制标题
多种力学方法治疗创伤性脑损伤：综述。
DOI：
10.3390/jcm12062179
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发表时间：
2023-03-11
影响因子：
3.9
通讯作者：
Li, Chunyan
中科院分区：
文献类型：
--
作者：
Lynch, Daniel G.;Narayan, Raj K.;Li, Chunyan
关键词：
创伤性脑损伤（TBI）是世界范围内死亡和残疾的主要原因。尽管进行了大量的研究工作，但迄今为止，大多数试验的单一疗法未能显示出显著的益处。有人认为，这是由于创伤性脑损伤的复杂病理生理，这可能是通过治疗干预的组合来解决的。在本文中，我们回顾了不同的药物治疗组合，非药物干预组合，以及药物和非药物联合干预治疗TBI。包括临床前和临床研究。虽然在动物模型中发现了令人鼓舞的结果，但联合疗法的临床试验尚未显示出明显的益处。这可能是由于它们的应用没有考虑到创伤性脑损伤的病理生理变化。这种模式的改进可能来自多模态神经监测和多模态成像技术指导的新干预措施，以及多靶向非药物和内源性治疗的应用。在临床前和临床研究中也需要有更多的女性受试者。
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Despite extensive research efforts, the majority of trialed monotherapies to date have failed to demonstrate significant benefit. It has been suggested that this is due to the complex pathophysiology of TBI, which may possibly be addressed by a combination of therapeutic interventions. In this article, we have reviewed combinations of different pharmacologic treatments, combinations of non-pharmacologic interventions, and combined pharmacologic and non-pharmacologic interventions for TBI. Both preclinical and clinical studies have been included. While promising results have been found in animal models, clinical trials of combination therapies have not yet shown clear benefit. This may possibly be due to their application without consideration of the evolving pathophysiology of TBI. Improvements of this paradigm may come from novel interventions guided by multimodal neuromonitoring and multimodal imaging techniques, as well as the application of multi-targeted non-pharmacologic and endogenous therapies. There also needs to be a greater representation of female subjects in preclinical and clinical studies.
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影响因子：
3.7
作者：
Acosta, Sandra A.;Tajiri, Naoki;Borlongan, Cesar V.
通讯作者：
Borlongan, Cesar V.
DOI：
10.1007/s10334-012-0316-9
发表时间：
2012-10
影响因子：
2.3
作者：
Storti, Silvia F.;Formaggio, Emanuela;Franchini, Enrica;Bongiovanni, Luigi G.;Cerini, Roberto;Fiaschi, Antonio;Michel, Christoph M.;Manganotti, Paolo
通讯作者：
Manganotti, Paolo
影响因子：
--
作者：
Alqahtani F;Assiri MA;Mohany M;Imran I;Javaid S;Rasool MF;Shakeel W;Sivandzade F;Alanazi AZ;Al-Rejaie SS;Alshammari MA;Alasmari F;Alanazi MM;Alamri FF
通讯作者：
Alamri FF
影响因子：
3.5
作者：
通讯作者：
--
影响因子：
2.9
作者：
Bleimeister, Isabel H.;Wolff, Mia;Kline, Anthony E.
通讯作者：
Kline, Anthony E.