Dissecting the mammalian genome--new insights into chromosomal evolution.
Dissecting the mammalian genome--new insights into chromosomal evolution.
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解剖哺乳动物基因组——染色体进化的新见解。
DOI：
10.1016/j.tig.2006.04.002
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Froenicke,Lutz
中科院分区：
文献类型：
--
作者：
Robinson,TerenceJ;Ruiz-Herrera,Aurora;Froenicke,Lutz
最近的一项研究比对了8种哺乳动物的基因组数据，提供了关于染色体结构的新的详细信息，这些染色体被认为构成了boreoeutherian祖先的核型。分析表明，进化断点聚集在“热点”，这些区域富含着丝粒，更常见的人类癌症相关断点往往与进化断点共定位。
A recent study aligning genomic data from eight mammalian species has provided new and detailed information on the architecture of chromosomes that are thought to comprise the karyotype of the boreoeutherian ancestor. The analyses suggest that evolutionary breakpoints are clustering in ‘hotspots’, that these regions are enriched for centromeres and that the more commonly occurring human cancer-associated breakpoints tend to co-localize with evolutionary breakpoints.