Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers
Nanostructures by self-assembling peptide amphiphile as potential selective drug carriers
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DOI：
10.1002/bip.20648
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发表时间：
2007-01-01
期刊：
影响因子：
2.9
通讯作者：
Morelli, Giancarlo
中科院分区：
文献类型：
--
作者：
Accardo, Antonella;Tesauro, Diego;Morelli, Giancarlo
报道了两亲肽（C18）（2）L5 CCK 8在生理pH下的纳米结构自组装行为。得到了临界胶束浓度为2 × 10（-6）mol/kg（-1）的稳定聚集体，其特征在于水暴露的CCK 8肽呈P-折叠构象。小角度中子散射实验指示尺寸>= 100 nm的3D结构。AFM图像证实了纳米结构的存在。荧光实验表明，芘的螯合，选择作为药物模型，和抗癌阿霉素的纳米结构内的报告。(c)2006 Wiley Periodicals，Inc. Biopolymers（Pept Sci）88：115-121，2007.
The self-assembling behaviour, at physiological pH, of the amphiphile peptide (C18)(2)L5CCK8 in nanostructures is reported. Stable aggregates presenting a critical micellar concentration of 2 X 10(-6) mol kg(-1), and characterized by water exposed CCK8 peptide in P-sheet conformation, are obtained. Small angle neutron scattering experiments are indicative for a 3D structure with dimensions >= 100 nm. AFM images confirm the presence of nanostructures. Fluorescence experiments indicating the sequestration of pyrene, chosen as drug model, and the anticancer Doxorubicin within the nanostructures are reported. (c) 2006 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 88: 115-121, 2007.