SEX EFFECTS IN DEFENSIVE BEHAVIOR - BASE-LINE DIFFERENCES AND DRUG-INTERACTIONS
SEX EFFECTS IN DEFENSIVE BEHAVIOR - BASE-LINE DIFFERENCES AND DRUG-INTERACTIONS
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DOI：
10.1016/s0149-7634(05)80132-0
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发表时间：
1991-12-01
影响因子：
8.2
通讯作者：
BLANCHARD, RJ
中科院分区：
文献类型：
--
作者：
BLANCHARD, DC;SHEPHERD, JK;BLANCHARD, RJ
与雄性大鼠相比，雌性大鼠在防御行为上始终表现出一种差异模式，这与在相同测试和测量中暴露于非疼痛性威胁刺激（猫或猫的气味）的影响相似。在涉及潜在威胁（而非实际和当前威胁）的情况下，雌性大鼠这种更强防御性的迹象尤为常见，这一因素可能也反映了在涉及非常强烈防御性的情况下的上限或下限效应。此外，药理学研究表明，选择性5 - 羟色胺（5 - HT）受体激动剂和拮抗剂对防御反应的影响存在性别差异。这些发现表明，在研究防御行为的药理学控制时必须考虑性别效应，并提示对性别效应的反应性可能是焦虑动物模型适用性的一个额外标准。
Female rats consistently show a pattern of differences in defensive behaviors compared to males which parallel the effects of exposure to a nonpainful threat stimulus (cat or cat odor) in the same tests and measures. These indications of greater defensiveness for females are particularly common in situations involving potential, as opposed to actual and present, threat, a factor which probably also reflects ceiling or floor effects in situations involving very intense defensiveness. In addition, pharmacological studies indicate sex differences in the effects of selective serotonin (5-HT) receptor agonists and antagonists on defensive responding. These findings indicate that sex effects must be considered in studies of the pharmacological control of defensive behaviors, and suggest that responsivity to sex effects may be an additional criterion for the suitability of animal models of anxiety.