Apoptosis in lymph nodes in acute African swine fever
Apoptosis in lymph nodes in acute African swine fever
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DOI：
10.1016/s0021-9975(96)80075-2
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发表时间：
1996-11-01
影响因子：
0.8
通讯作者：
Sierra, MA
中科院分区：
文献类型：
--
作者：
Carrasco, L;deLara, FCM;Sierra, MA
本文报道了实验性接种强毒力非洲猪瘟 (ASF) 病毒分离株（马拉维'83）的猪体内淋巴结淋巴细胞的凋亡。在皮质组织的两个区室中均观察到细胞凋亡，但在弥漫性淋巴组织（T 区）中更为强烈。外周血中检测到的淋巴细胞减少与 T 淋巴细胞耗竭有关。在所研究的淋巴结的淋巴细胞中没有观察到非洲猪瘟病毒复制的证据。这一发现，加上弥漫性淋巴组织巨噬细胞中记录的高病毒复制率（与淋巴滤泡中记录的低病毒复制率相比），提示了单核吞噬细胞系统细胞中与病毒复制相关的诱导细胞凋亡的机制。 (C) 1996 W.B.桑德斯有限公司
This paper reports apoptosis of lymph-node lymphocytes in swine experimentally inoculated with a virulent African swine fever (ASF) virus isolate (Malawi '83). Apoptosis was observed in both compartments of cortical tissue, but was more intense in diffuse lymphoid tissue (T area). Lymphopenia detected in peripheral blood was associated with T-lymphocyte depletion. No evidence of ASF virus replication was observed in lymphocytes in the lymph nodes studied. This finding, together with the high rate of virus replication recorded in macrophages in diffuse lymphoid tissue as compared with the low rate recorded for lymphoid follicles, suggests a mechanism for the induction of apoptosis related to virus replication in cells of the mononuclear phagocyte system. (C) 1996 W.B. Saunders Company Limited