Diffusion and interaction in PEG-DA hydrogels
Diffusion and interaction in PEG-DA hydrogels
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DOI：
10.1186/1559-4106-8-36
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发表时间：
2013-12-06
期刊：
影响因子：
2.1
通讯作者：
Boehm, Heike
中科院分区：
文献类型：
--
作者：
Hagel, Valentin;Haraszti, Tamas;Boehm, Heike
聚乙二醇（PEG）水凝胶由于其良好的生物相容性和高亲水性而被广泛用作生物和技术应用的可调基质。在这里，我们通过分析具有不同、明确尺寸的溶质在长和短时间尺度上的扩散来比较 PEG 水凝胶的网格尺寸和扩散特性。有趣的是，人们可以通过改变 PEG-二丙烯酸酯 (PEG-DA) 聚合物的初始浓度来调节凝胶的网格尺寸和密度，这也可以通过与 PEG 链的相互作用增强平衡状态下的溶质吸收。这种增加的吸收可以通过分配比分析确定的增强因子来表征。它随着聚合物体积分数线性增加，但不是由水凝胶内部的固定引起的，如 FRAP 测量所示，因此使这些水凝胶成为药物输送应用的理想材料。
Polyethylenglycol (PEG) hydrogels are widely used as tuneable substrates for biological and technical applications due to their good biocompatibility and their high hydrophilicity. Here we compare the mesh size and diffusion characteristics of PEG hydrogels by analyzing the diffusion of solutes with different, well-defined sizes over long and short time scales. Interestingly, one can tune the mesh size and the density of the gel simply by changing the inital concentrations of the PEG-diacrylate (PEG-DA) polymer, which also enhances the solute uptake in equilibrium through the interaction with the PEG chains. This increased uptake can be characterized by an enhancement factor determined by partition ratio analysis. It increases linearly with the polymer volume fraction, but is not caused by immobilization inside the hydrogel as evident from FRAP measurements, thus rendering these hydrogels ideal materials for i.e. drug delivery applications.