Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development.
Expanding the Junction: New Insights into Non-Occluding Roles for Septate Junction Proteins during Development.
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DOI：
10.3390/jdb9010011
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发表时间：
2021-03-21
影响因子：
2.7
通讯作者：
Ward RE
中科院分区：
文献类型：
--
作者：
Rice C;De O;Alhadyian H;Hall S;Ward RE
在无脊椎动物中，隔膜连接（SJ）为上皮组织提供闭塞功能。这种密封细胞之间的细胞旁途径的能力允许内部组织为器官功能创建独特的隔室，并赋予表皮屏障功能以限制病原体的通过。在过去的25年里，许多研究人员已经确定了超过30种蛋白质，这些蛋白质是果蝇中形成或维持SJS所必需的，并且已经确定了连接生物发生中涉及的许多步骤。沿着，已经清楚的是SJ蛋白也是生物体整个生命中发生的许多发育事件所必需的。这些发育事件中的许多发生在闭塞连接形成之前，表明SJ蛋白具有非闭塞功能。在这篇综述中，我们将描述的组成，SJS，注意到哪些蛋白质是核心组成部分的交界处与居民或辅助蛋白质，以及参与的步骤中的生物发生的交界处。然后，我们将详细说明核心SJ蛋白可能发挥的功能以外的作用，在形成闭塞连接和描述的研究，提供了一些细胞生物学的观点，开始提供这些蛋白质如何在发育环境中发挥作用的机制的理解。
The septate junction (SJ) provides an occluding function for epithelial tissues in invertebrate organisms. This ability to seal the paracellular route between cells allows internal tissues to create unique compartments for organ function and endows the epidermis with a barrier function to restrict the passage of pathogens. Over the past twenty-five years, numerous investigators have identified more than 30 proteins that are required for the formation or maintenance of the SJs in Drosophila melanogaster, and have determined many of the steps involved in the biogenesis of the junction. Along the way, it has become clear that SJ proteins are also required for a number of developmental events that occur throughout the life of the organism. Many of these developmental events occur prior to the formation of the occluding junction, suggesting that SJ proteins possess non-occluding functions. In this review, we will describe the composition of SJs, taking note of which proteins are core components of the junction versus resident or accessory proteins, and the steps involved in the biogenesis of the junction. We will then elaborate on the functions that core SJ proteins likely play outside of their role in forming the occluding junction and describe studies that provide some cell biological perspectives that are beginning to provide mechanistic understanding of how these proteins function in developmental contexts.