Revisiting the Mechanisms of CNS Immune Privilege.
Revisiting the Mechanisms of CNS Immune Privilege.
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重新审视CNS免疫特权的机制。
DOI：
10.1016/j.it.2015.08.006
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发表时间：
2015-10
影响因子：
16.8
通讯作者：
Kipnis J
中科院分区：
文献类型：
--
作者：
Louveau A;Harris TH;Kipnis J
虽然免疫系统和中枢神经系统（CNS）之间的相互作用的研究往往集中在病理条件下，神经免疫通讯在CNS稳态和功能的重要性在过去的二十年已经变得清晰。在这里，我们讨论了我们对外周免疫系统和中枢神经系统之间相互作用的理解的进展。我们研究的概念，免疫豁免的中枢神经系统的早期发现和最近的研究揭示了功能性脑膜淋巴系统，引流脑脊液（CSF）的颈深淋巴结，并考虑了不同的神经系统疾病的病因学和病理学的中枢神经系统的免疫豁免的修订观点的影响。
Whereas the study of the interactions between the immune system and the central nervous system (CNS) has often focused on pathological conditions, the importance of neuroimmune communication in CNS homeostasis and function has become clear over that last two decades. Here we discuss the progression of our understanding of the interaction between the peripheral immune system and the CNS. We examine the notion of immune privilege of the CNS in light of both earlier findings and recent studies revealing a functional meningeal lymphatic system that drains cerebrospinal fluid (CSF) to the deep cervical lymph nodes, and consider the implications of a revised perspective on the immune privilege of the CNS on the etiology and pathology of different neurological disorders.