A model of excitation and adaptation in bacterial chemotaxis
A model of excitation and adaptation in bacterial chemotaxis
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DOI：
10.1073/pnas.94.14.7263
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发表时间：
1997-07-08
影响因子：
11.1
通讯作者：
Othmer, HG
中科院分区：
文献类型：
--
作者：
Spiro, PA;Parkinson, JS;Othmer, HG
细菌趋化性因其可及性而受到广泛研究，并且因为它结合了许多感觉系统中重要的过程：信号转导、兴奋、适应和行为变化，所有这些都是对刺激的反应。该系统可以获得有关行为变化的定量数据，并且已经确定了信号转导/处理途径中的主要生化步骤。我们已将最新的生化数据纳入数学模型中，该模型可以重现细胞内反应的许多主要特征，包括趋化蛋白水平对步进和斜坡刺激的变化，例如实验方案中使用的刺激。趋化蛋白与运动蛋白的相互作用没有被建模，但我们可以在趋化蛋白与运动蛋白直接相互作用的假设下估计产生观察到的增益所需的协同程度。
Bacterial chemotaxis is widely studied because of its accessibility and because it incorporates processes that are important in a number of sensory systems: signal transduction, excitation, adaptation, and a change in behavior, all in response to stimuli. Quantitative data on the change in behavior are available for this system, and the major biochemical steps in the signal transduction/processing pathway have been identified. We have incorporated recent biochemical data into a mathematical model that can reproduce many of the major features of the intracellular response, including the change in the level of chemotactic proteins to step and ramp stimuli such as those used in experimental protocols. The interaction of the chemotactic proteins with the motor is not modeled, but we can estimate the degree of cooperativity needed to produce the observed gain under the assumption that the chemotactic proteins interact directly with the motor proteins.