Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma
Frequent loss of imprinting at the IGF2 and H19 genes in head and neck squamous carcinoma
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DOI：
10.1038/sj.onc.1203192
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发表时间：
1999-11-25
期刊：
影响因子：
8
通讯作者：
Huff, V
中科院分区：
文献类型：
--
作者：
El-Naggar, AK;Lai, SL;Huff, V
基因组印记是一种遗传性表观遗传现象，导致体细胞中亲本来源特异性基因表达。某些基因的这一特征的松弛或丧失已在一些儿科和成人肿瘤中得到证实，表明与肿瘤发生有关。我们分析了 64 例未经治疗的原发性头颈部鳞状细胞癌中 IGF2 和 H19 基因印记的丢失，以确定这种改变对这些肿瘤发生和进展的影响。 64 个肿瘤中的 49 个（77%）为这些基因的印记分析提供了信息。 IGF2 和 H19 印记在所有检查的正常鳞状上皮中。 32 个提供 H19 信息的肿瘤中的 12 个（37.5%）和 27 个提供 IGF2 信息的肿瘤中的 11 个（40.7%）表现出印记丢失。十个肿瘤对这两个基因都有信息，其中四个保留了结构印记，六个显示 H19 或 IGF2 印记丢失。这些数据表明 IGF2 和 H19 基因座印记的丢失在头颈癌的肿瘤发生中发挥作用。
Genomic imprinting is an inherited epigenetic phenomenon that results in parental-origin-specific gene expression in somatic cells. Relaxation or loss of this feature in certain genes has been demonstrated in several pediatric and adult neoplasms, suggesting an association with tumorigenesis. We analysed 64 primary untreated head and neck squamous carcinoma for the loss of imprinting in the IGF2 and H19 genes to determine the implications of this alteration in the development and progression of these tumors. Forty-nine (77%) of the 64 tumors were informative for imprinting analyses of these genes. IGF2 and H19 were imprinted in all normal squamous epithelium examined. Twelve (37.5%) of 32 tumors informative for H19 and 11 (40.7%) of 27 tumors informative for IGF2 manifested loss of imprinting. Ten tumors were informative for both genes, of which four maintained the constitutional imprinting and six showed loss of imprinting at either H19 or IGF2. These data suggest that loss of imprinting at the IGF2 and H19 loci play a role in the oncogenesis of head and neck carcinoma.