Reservoirs of human immunodeficiency virus type 1: the main obstacles to viral eradication.
Reservoirs of human immunodeficiency virus type 1: the main obstacles to viral eradication.
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人类免疫缺陷病毒1型宿主：根除病毒的主要障碍。
DOI：
10.1086/338256
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Pomerantz,RogerJ
中科院分区：
文献类型：
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作者：
Pomerantz,RogerJ
至少在发达国家，高效抗逆转录病毒疗法（HAART）已导致1型人类免疫缺陷病毒（HIV-1）感染者的发病率和死亡率大幅下降。由于联合抗逆转录病毒治疗，许多感染者的血浆HIV-1 RNA水平低于大多数临床检测的检测限。尽管如此，HAART并没有根除HIV-1。这已被证明是因为潜伏的HIV-1复制能力的前病毒在休息的CD 4 +T淋巴细胞，隐藏的病毒复制低于大多数临床检测的检测限，并可能，病毒避难所网站的存在。了解这些水库的HIV-1的病毒抑制HAART的设置将是至关重要的新方法，以诱导HIV-1缓解的发展和探索的可能性，在未来的病毒根除。
Highly active antiretroviral therapy (HAART) has led to profound decreases in morbidity and mortality rates in human immunodeficiency virus type 1 (HIV-1)–infected persons, at least in the developed world. Many infected persons have plasma levels of HIV-1 RNA that are less than the limits of detection of most clinical assays as a result of combination antiretroviral therapy. Nonetheless, HIV-1 has not been eradicated by HAART. This has been shown to be because of latent HIV-1 replication-competent provirus in resting CD4+T lymphocytes, cryptic viral replication below the limits of detection of most clinical assays, and, possibly, the presence of viral sanctuary sites. An understanding of these reservoirs for HIV-1 in the setting of virally suppressive HAART will be critical for the development of new approaches to induce HIV-1 remissions and for the exploration of the possibility of viral eradication in the future.