Studies on the toxicity of typhus rickettsiae. I. Susceptibility of the white rat, with a note on pathologic changes.
Studies on the toxicity of typhus rickettsiae. I. Susceptibility of the white rat, with a note on pathologic changes.
复制标题
斑疹伤寒立克次体毒性的研究。
DOI：
10.1093/infdis/91.1.72
复制
发表时间：
1952
期刊：
影响因子：
--
通讯作者：
J. C. Snyder
中科院分区：
文献类型：
--
作者：
F. Neva;J. C. Snyder
报道了白鼠对静脉注射活斑疹伤寒立克次体毒性的敏感性。有证据表明，这种毒性是由活斑疹伤寒立克次体引起的，并且与小白鼠的现象相似。对大鼠和小鼠的毒性剂量进行反复滴定，结果表明，以体重为基础，大鼠对流行性斑疹伤寒立克次体的急性毒性与小鼠一样敏感，但对鼠斑疹伤寒立克次体的毒性比小鼠更耐药。急性立克次体中毒死亡大鼠小肠观察到大体病理改变。
Susceptibility of the white rat to the toxic properties of intravenously administered living typhus rickettsiae is reported. Evidence is presented which shows that the toxicity is due specifically to living typhus rickettsiae and is similar to the phenomenon in white mice. In repeated titrations of the toxic dose for rats as compared with mice, it was shown that the white rat is as susceptible as the mouse on a body weight basis to acute toxicity with epidemic typhus rickettsiae, but more resistant than the mouse to toxicity with rickettsiae of murine typhus. Gross pathologic changes were observed in the small intestine of white rats dying of acute rickettsial toxicity.