Vitamin D concentrations and COVID-19 infection in UK Biobank
Vitamin D concentrations and COVID-19 infection in UK Biobank
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DOI：
10.1016/j.dsx.2020.04.050
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发表时间：
2020-07-01
影响因子：
10
通讯作者：
Pell, Jill P.
中科院分区：
文献类型：
--
作者：
Hastie, Claire E.;Mackay, Daniel F.;Pell, Jill P.
背景和目的：COVID-19和维生素D水平低似乎对黑人和少数民族个体的影响不成比例。我们旨在确定血液中25-羟基维生素D（25（OH）D）浓度是否与COVID-19风险相关，以及它是否解释了黑人和南亚人COVID-19的高发病率。方法：英国生物银行在2006年至2010年期间招募了502,624名年龄在37-73岁之间的参与者。基线暴露数据，包括25（OH）D浓度和种族，与COVID-19检测结果相关。对25（OH）D与确诊的COVID-19之间的关联以及种族与25（OH）D和COVID-19之间的关联进行了单变量和多变量logistic回归分析。结果：348，598名英国生物银行参与者的完整数据可用。其中449人已确认感染COVID-19。维生素D与COVID-19感染的一致性相关（OR = 0.99; 95% CI 0.99-0.999; p = 0.013），但在调整混杂因素后不相关（OR = 1.00; 95% CI = 0.998-1.01; p = 0.208）。种族与COVID-19感染一致性相关（黑人与白人OR = 5.32，95% CI = 3.68-7.70，p值
Background and aims: COVID-19 and low levels of vitamin D appear to disproportionately affect black and minority ethnic individuals. We aimed to establish whether blood 25-hydroxyvitamin D (25(OH)D) concentration was associated with COVID-19 risk, and whether it explained the higher incidence of COVID-19 in black and South Asian people.Methods: UK Biobank recruited 502,624 participants aged 37-73 years between 2006 and 2010. Baseline exposure data, including 25(OH)D concentration and ethnicity, were linked to COVID-19 test results. Univariable and multivariable logistic regression analyses were performed for the association between 25(OH)D and confirmed COVID-19, and the association between ethnicity and both 25(OH)D and COVID-19.Results: Complete data were available for 348,598 UK Biobank participants. Of these, 449 had confirmed COVID-19 infection. Vitamin D was associated with COVID-19 infection univariably (OR = 0.99; 95% CI 0.99-0.999; p = 0.013), but not after adjustment for confounders (OR = 1.00; 95% CI = 0.998-1.01; p = 0.208). Ethnicity was associated with COVID-19 infection univariably (blacks versus whites OR = 5.32, 95% CI = 3.68-7.70, p-value