Trends in substitution models of molecular evolution.
Trends in substitution models of molecular evolution.
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DOI：
10.3389/fgene.2015.00319
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发表时间：
2015
影响因子：
3.7
通讯作者：
Arenas M
中科院分区：
文献类型：
--
作者：
Arenas M
替代进化模型描述了通过固定突变的遗传变异过程，构成了分子水平上进化分析的基础。在第一个替代模型发展近40年后，高度复杂的、数据特定的替代模型继续出现，目的是更好地模拟真实的进化过程。在这里，我描述了目前的趋势，在替代模型的DNA，密码子和氨基酸序列的进化，包括最流行的模型的优点和缺陷。该观点的结论是，尽管目前有大量的替代模型，但需要进一步的研究来进行更真实的建模，特别是对于DNA编码和氨基酸数据。此外，更准确的复杂模型的开发应与替代模型选择和下游进化分析的方法和框架的新实现和改进相结合。
Substitution models of evolution describe the process of genetic variation through fixed mutations and constitute the basis of the evolutionary analysis at the molecular level. Almost 40 years after the development of first substitution models, highly sophisticated, and data-specific substitution models continue emerging with the aim of better mimicking real evolutionary processes. Here I describe current trends in substitution models of DNA, codon and amino acid sequence evolution, including advantages and pitfalls of the most popular models. The perspective concludes that despite the large number of currently available substitution models, further research is required for more realistic modeling, especially for DNA coding and amino acid data. Additionally, the development of more accurate complex models should be coupled with new implementations and improvements of methods and frameworks for substitution model selection and downstream evolutionary analysis.