Jug-PLGA-NPs, a New Form of Juglone with Enhanced Efficiency and Reduced Toxicity on Melanoma
Jug-PLGA-NPs, a New Form of Juglone with Enhanced Efficiency and Reduced Toxicity on Melanoma
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Jug-PLGA-NPs，一种新形式的胡桃醌，对黑色素瘤具有更高的效率和更低的毒性
DOI：
10.1007/s11655-021-3461-y
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发表时间：
2021-12-15
影响因子：
2.9
通讯作者：
Zou，Zheng-yun
中科院分区：
文献类型：
--
作者：
Yue，Wu-heng;Qin，Lan-qun;Zou，Zheng-yun
目的验证胡桃醌（Jug）及其载药纳米粒（Jug-PLGA-NPs）的抗肿瘤疗效和毒性。采用MTT法和细胞凋亡分析法检测Jug（2，3，4 μg/mL）和Jug-PLGA-NPs（Jug：2，3，4 μg/mL）的体外抗肿瘤活性。结果Jug-PLGA-NPs具有良好的渗透性和靶向性，在体外和体内均能显著抑制黑色素瘤细胞的增殖和迁移（P<0.05或P <0.01），并具有良好的生物相容性。Jug-PLGA-NPs具有缓释、肿瘤靶向性、抗肿瘤活性和可接受的生物安全性等优点，为Jug的进一步应用提供了新的剂型。
ObjectiveTo verrify the anti-tumor efficacy and toxicity between juglone (Jug) and Jug-loaded PLGA nanoparticles (Jug-PLGA-NPs).MethodsJug-PLGA-NPs were prepared by ultrasonic emulsification. The anti-tumor activity of Jug (2, 3, 4 µg/mL) and Jug-PLGA-NPs (Jug: 2, 3, 4 µg/mL)in vitrowas measured by MTT assay and cell apoptosis analysis. The distribution, anti-tumor effect and biological safetyin vivowas evaluated on A375 nude mice.ResultsWith the advantage of good penetration and targeting properties, Jug-PLGA-NPs significantly inhibited proliferation and migration of melanoma cells bothin vitroandin vivo(P<0.05 orP<0.01) with acceptable biocompatibility.ConclusionsJug can inhibit the growth of melanoma but is highly toxic. With the advantage of sustained release, tumor targeting, anti-tumor activity and acceptable biological safety, Jug-PLGA-NPs provide a new pharmaceutical form for future application of Jug.